2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-151

Antitumor agent-151 (7k) 是一种显著的HsClpP激动剂和一种抗白血病药物候选物。Antitumor agent-151 (7k) 显著增强了HsClpP的蛋白水解活性（EC50 = 0.79 μM）和体外抗肿瘤活性 (IC50 = 0.038 μM)。Antitumor agent-151 (7k) 可诱导凋亡。

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Antitumor agent-151 Chemical Structure

Antitumor agent-151 Chemical Structure

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     可免费申领三个不同产品的试用装。

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Antitumor agent-151 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-151 (7k) is a significant HsClpP agonist and an antileukemia drug candidate. Antitumor agent-151 (7k) exhibits remarkably enhanced proteolytic activity of HsClpP (EC50 = 0.79 μM) and antitumor activity in vitro (IC50 = 0.038 μM). Antitumor agent-151 (7k) induces apoptosis[1].
体外研究
(In Vitro)

Antitumor agent-151 (7k) 对 AML 细胞系有较强的抑制活性，其在 Molm13、U937、OCI-AML2、THP-1、HL60、KASSUMI、和 K562 细胞系中的 IC50 值分别为 30.1 ± 2.3、78.2 ± 3.1、39.2 ± 0.9、79.7 ± 0.3、40.5 ± 0.8、41.1 ± 1.7 和 131.8 ± 1.5 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-151 相关抗体:
体内研究
(In Vivo)

Antitumor agent-151 (7k，10 mg/kg，腹腔注射，携带Mv4-11急性髓系白血病细胞的雌性 BALB/c 裸鼠) 显示出强大的抗肿瘤效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

389.43

Formula

C22H20FN5O
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-151 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-151Antitumor agent151Antitumor agent 151ApoptosisAMLapoptosisantitumorHsClpPInhibitorinhibitorinhibit

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