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  4. Antitumor agent-91

Antitumor agent-91 是一种环磷酸酯衍生物，具有抗癌活性和抗增殖活性。Antitumor agent-91 在人类去势抵抗性前列腺癌和胰腺癌中有潜在应用。

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Antitumor agent-91 Chemical Structure

Antitumor agent-91 Chemical Structure

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Antitumor agent-91 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-91 is a cyclic phosphate ester derivative with anticancer and anti-proliferative activities. Antitumor agent-91 has potential application in human castration resistant prostate cancer and pancreatic cancer[1].

体外研究
(In Vitro)

Antitumor agent-91 (Compound 18c) 对 MM1. S、BxPC-3、MP-2、22Rv1、MV4-11、Jeko-1 和 HUH7 细胞具有抗肿瘤活性，IC50 值分别为 3.6 nM、16.5 nM、12.5 nM、10.6 nM、5.4 nM、19.2 nM 和 16.2 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-91 相关抗体:

Western Blot Analysis[1]

Cell Line: BxPC-3 cells.
Concentration: 25 nM, 50 nM and 100 nM.
Incubation Time: 24 h.
Result: Increased the expression of P21.

Cell Cycle Analysis[1]

Cell Line: BxPC-3 cells.
Concentration: 25 nM, 50 nM and 100 nM.
Incubation Time: 24 h.
Result: Induced cell S phase arrest.
体内研究
(In Vivo)

Antitumor agent-91 (Compound 18c) (50 mg/kg；腹腔注射；一周两次持续四周) 在植入 22Rv1 肿瘤的去势雄性 Balb/c 裸鼠模型中显著抑制了肿瘤增长[1]。
Antitumor agent-91 在比格犬中的药代动力学 (PK) 参数[1]

Route Dose (mg/kg) AUC0-∞ (h•ng/mL) T1/2 (h) CL (mL/h/kg) Cmax (ng/mL)
Intravenous injection 1 520.24±79.49 0.12±0.046 1952±295 3600.3±325.59

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

473.32

Formula

C18H18F2N3O8P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-91 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-91Antitumor agent91Antitumor agent 91OthersBeagle DogsBalb/c nude mouse22Rv1BxPC-3 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
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