2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. AP102

AP102 是一种 SSTR2/SSTR5 特异性生长抑素类似物 (SSA)。 AP102 是一种二硫桥八肽 SSA，含有合成的碘化氨基酸。 AP102 以亚纳摩尔亲和力与 SSTR2 和 SSTR5 结合 (IC50：分别为 0.63 和 0.65 nM)。AP102 不结合 SSTR1 或 SSTR3。AP102 可用于肢端肥大症和神经内分泌肿瘤研究。

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AP102 Chemical Structure

AP102 Chemical Structure

CAS No. : 846569-60-6

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     可免费申领三个不同产品的试用装。

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规格 是否有货
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Customer Review

AP102 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].

IC50 & Target

SSTR2

0.63 nM (IC50)

SSTR5

0.65 nM (IC50)

体外研究
(In Vitro)

AP102 在体外抑制大鼠垂体前叶细胞 GHRH 刺激的 GH 释放和催乳素释放。 GH 和催乳素抑制的 IC50 水平较低（分别为 0.15 和 0.23 nM）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AP102 相关抗体:
体内研究
(In Vivo)

AP102 (0-30 µg/kg, 皮下注射) 在健康大鼠模型中急性或慢性给药期间可急剧降低生长激素，但不会引起高血糖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1313.07

Formula

C50H66I2N12O10S2
CAS 号
Sequence

{4-amino-3-iodo-d-Phe}-Cys-(3-iodo-Tyr}-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

{4-amino-3-iodo-d-Phe}-C-(3-iodo-Tyr}-{d-Trp}-KVCT-NH2 (Disulfide bridge: Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

AP102 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AP102846569-60-6AP 102AP-102Somatostatin ReceptorSSTRsSSTRInhibitorinhibitorinhibit

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目录号：
HY-P2434
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