2. 诱导疾病模型产品 Immunology/Inflammation Anti-infection NF-κB Autophagy Apoptosis MAPK/ERK Pathway
  3. 免疫与炎症疾病模型 消化系统疾病模型 COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK
  4. 胃肠炎症及溃疡模型 胃肠道疾病模型
  5. 胃溃疡模型
  6. Aspirin lithium

Aspirin lithium  (Synonyms: Acetylsalicylic Acid lithium; ASA lithium)

目录号: HY-14654A
产品使用指南

摩尔计算器

Aspirin (Acetylsalicylic Acid) lithium 是一种口服有效的不可逆的环氧合酶 COX-1 和 COX-2 抑制剂，IC50 分别为 5 和 210 μg/mL. Aspirin lithium 诱导细胞凋亡 (apoptosis)。Aspirin lithium 可抑制 NF-κB 的活化。Aspirin lithium 还抑制血小板前列腺素合成酶 (prostaglandin synthetase)，可预防冠状动脉和脑血管血栓形成。

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Aspirin lithium Chemical Structure

Aspirin lithium Chemical Structure

CAS No. : 552-98-7

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Aspirin lithium 的其他形式现货产品:

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Other Forms of Aspirin lithium:

Aspirin lithium 相关抗体

Top Publications Citing Use of Products

    Aspirin lithium purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

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    COX COX-1 COX-2 COX-3

    查看 NF-κB 亚型特异性产品:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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    p38 MAPK p38α p38β MAPK13 p38δ p38γ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].

    IC50 & Target

    COX-1

     

    COX-2

     

    体外研究
    (In Vitro)

    Aspirin lithium inhibits COX-1 and COX-2 in human articular chondrocytes, with IC50 values of 3.57 μM and 29.3 μM, respectively[2].
    Aspirin lithium acetylates serine-530 of COX-1, thereby blocking thromboxane A synthesis in platelets and reducing platelet aggregation[3].
    Aspirin lithium inhibits COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer[3].
    Aspirin lithium inhibits NF-κB-dependent transcription from the lgκ enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells[4].
    Aspirin lithium induces apoptosis by the activation of caspases, the activation of p38 MAP kinase, release of mitochondrial cytochrome c, and activation of the ceramide pathway[6].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Aspirin lithium 相关抗体:
    体内研究
    (In Vivo)

    Aspirin lithium (5-150 mg/kg, PO, once) shows significant antipyretic activity in adult yeast-fevered male rats[7].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male albino Charles River rats (200-250 g, 8 animals/group, fever was induced by 20 ml/kg of a 20 % aqueous suspension of brewer’s yeast which was injected SC in the back below the nape of the neck)[7]
    Dosage: 5, 25, 50, 100 and 150 mg/kg
    Administration: PO, once
    Result: Produced a statistically significant decrease of 0.23 ℃ at 15 min post-drug at the dose of 150 mg/kg. Antipyretic effect gradually increased in magnitude until a peak effect of 1.96 ℃ was reached at 120 min post-drug. The ED50 of aspirin was found to be 10.3 mg/kg with confidence limits of 1.8-23.0 mg/kg. The antipyretic response to aspirin is dependent on the dose of the compound administered.
    Clinical Trial
    分子量

    186.09

    Formula

    C9H7LiO4
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Aspirin lithium 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aspirin552-98-7Acetylsalicylic AcidASACOXVirus ProteaseNF-κBAutophagyApoptosisMitophagyCaspasep38 MAPKCyclooxygenaseNuclear factor-κBNuclear factor-kappaBMitochondrial AutophagyAntipyretic effectfeverinflammationcerebrovascular thrombosiscoronary arteryplateletprostaglandin synthetasecancerInhibitorinhibitorinhibit

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