2. Apoptosis
  3. RIP kinase
  4. AV123

AV123 (化合物 12) 是一种无细胞毒性的 RIPK1 抑制剂 (IC50=12.12 µM)。AV123 能抑制 TNF-α 诱导的坏死性细胞死亡 (EC50=1.7 μM)，但不阻止凋亡性细胞的死亡。AV123 可用于坏死的慢性病症，如脑、心和肾的缺血再灌注损伤、炎症性疾病、神经退行性疾病和感染性疾病的研究。

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AV123 Chemical Structure

AV123 Chemical Structure

CAS No. : 233605-81-7

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AV123 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].

IC50 & Target

IC50: 0.48 µM (CDK9/ CyclinT), 0.80 µM (CLK1 of Mus musculus), 1.80 µM (DYRK1A of Rattus norvegicus), >10 µM (CDK2/CyclinA, CDK5/p25, HASPIN, Pim1, CK1 ε, JAK3, ABL1, RIPK3, AURKB)[1].
体外研究
(In Vitro)

AV123 (0.01-100 µM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells[1].
AV123 (0.01-50 µM; 24 h) shows no toxicity to RPE-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AV123 相关抗体:

Cell Viability Assay[1]

Cell Line: FADD-deficient Jurkat cells
Concentration: 0.01-100 µM
Incubation Time: 24 h
Result: Significantly blocked the necroptotic cell-death induced by TNF-α with an EC50 value of 1.7 µM.

Cell Cytotoxicity Assay[1]

Cell Line: RPE-1 cells
Concentration: 0.01-50 µM
Incubation Time: 24 h
Result: Exhibited no toxicity to RPE-1 cells.
分子量

234.25

Formula

C11H14N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AV123 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV123233605-81-7AV 123AV-123RIP kinaseReceptor-interacting protein kinasesRIPKnecroptosisFADD-deficient Jurkat cellsRPE-1 cellsRCDInhibitorinhibitorinhibit

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