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  3. Belvarafenib TFA

Belvarafenib TFA 

目录号: HY-109080A 纯度: >99.0%
产品使用指南

Belvarafenib (TFA) 是一种有效的,广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂,其对 B-RAF,B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。

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Belvarafenib TFA Chemical Structure

Belvarafenib TFA Chemical Structure

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5 mg ¥3500 In-stock
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Description

Belvarafenib (TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1].

IC50 & Target

IC50: 56 nM(B-RAF), 7 nM(B-RAFv600E), 5 nM(C-RAF)[1].

In Vitro

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

592.95

Formula

C₂₅H₁₇ClF₄N₆O₃S

SMILES

O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Belvarafenib TFA
目录号:
HY-109080A
需求量:

Belvarafenib TFA

Cat. No.: HY-109080A