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  4. BIM5078

BIM5078 是一种肝细胞核因子 4α (HNF4α) 拮抗剂，可抑制已知 HNF4α 靶基因的表达。BIM507 通过 HNF4α 拮抗作用抑制胰岛素启动子活性。BIM5078 可用于癌症和糖尿病的研究。

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BIM5078 Chemical Structure

BIM5078 Chemical Structure

CAS No. : 337506-43-1

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BIM5078 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1].

IC50 & Target

hepatocyte nuclear factor 4α (HNF4α)[1]
体外研究
(In Vitro)

BIM5078 (0.63-5 μM；48 h) 抑制内源性胰岛素在 T6PNE 细胞中的表达，IC50 值为 930 nM[1]。
BIM5078 (2.5-10 μM；5-48 h) 在 HepG2 细胞中抑制 HNF4α 基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BIM5078 相关抗体:
分子量

351.76

Formula

C14H10ClN3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BIM5078 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIM5078337506-43-1BIM 5078BIM-5078OthersHNF4αAntagonistT6PNEInhibitorinhibitorinhibit

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