Biotin-COG1410 TFA 

Biotin-COG1410 TFA is a biotin labled COG1410 (HY-P2136). COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease^[1][2].

Cog1410 (1-25 μm; 48 h) 降低 BV2 小胶质细胞 NO 和 TNFα 的产生和释放^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

COG1410 (0.3-0.6 mg/kg；单次静脉注射) 对小鼠前庭运动功能的短期测试和空间学习和记忆的长期测试有显著改善^[1]。
COG1410 (0.8 mg/kg；单次静脉注射) 可改善大鼠前庭运动功能，减少脑卒中后运动不对称性，并减少同侧半球梗死体积^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₇₄H₁₃₅N₂₃O₁₆S.xC₂HF₃O₂

固体

White to off-white

Ac-AS-{Aib}-LRKL-{Aib}-Lys(Biotin)-RLL-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107.   [Content Brief]

  [2]. Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82.  [Content Brief]

  [3]. Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980.  [Content Brief]