2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Bisabosqual A

Bisabosqual A，一种有效的天冬酰胺合成酶 (ASNS) 抑制剂，IC50 为 10.7 μM。Bisabosqual A 能够共价修饰 ASNS 蛋白的 K556 位点。Bisabosqual A 促进氧化应激和细胞凋亡 (apoptosis)，同时抑制自噬 (autophagy)、细胞迁移和上皮间质转化 (EMT)，阻碍癌细胞发展。

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Bisabosqual A Chemical Structure

Bisabosqual A Chemical Structure

CAS No. : 180027-46-7

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Bisabosqual A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bisabosqual A, a potent asparagine synthetase (ASNS) inhibitor, with an IC50 of 10.7 μM. Bisabosqual A can covalently modify the K556 site of ASNS protein. Bisabosqual A promotes oxidative stress and apoptosis, while inhibiting autophagy, cell migration and epithelial-mesenchymal transition (EMT), impeding cancer cell development[1].

体外研究
(In Vitro)

Bisabosqual A 抑制人非小细胞肺癌 A549 细胞的增殖和迁移[1]。
Bisabosqual A 诱导包含 GCN2-eIF2α-ATF4、PI3K-AKT-mTORC1 和 RAF-MEK-ERK 轴的负反馈通路，但 Bisabosqual A 和雷帕霉素/torin-1 的联合作用克服了 mTOR 通路触发的潜在耐药性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bisabosqual A 相关抗体:
分子量

384.47

Formula

C23H28O5
CAS 号
结构分类
初始来源

Stachybotrys sp. RF-7260
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bisabosqual A 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisabosqual A180027-46-7ApoptosisAutophagyInhibitorinhibitorinhibit

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