2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-19

BTK-IN-19 (Compound 51) 是一种可逆的 BTK 抑制剂，IC50 <0.001 μM。

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BTK-IN-19 Chemical Structure

BTK-IN-19 Chemical Structure

CAS No. : 1374240-01-3

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BTK-IN-19 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTK-IN-19 (Compound 51) is a reversible BTK inhibitor with an IC50 of <0.001 μM[1].

IC50 & Target

IC50: <0.001 μM (BTK)[1]
体外研究
(In Vitro)

BTK-IN-19 (Compound 51) (3 days) inhibits B-cell proliferation with an IC50 of 0.080 μM[1]. BTK-IN-19 (Compound 51) (3 days) 抑制 B 细胞增殖，IC50 为 0.080 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-19 相关抗体:

Cell Proliferation Assay[1]

Cell Line: B cells enriched from PBMC
Concentration:
Incubation Time: 3 days
Result: Inhibited B-cell proliferation with an IC50 of 0.080 μM.
体内研究
(In Vivo)

BTK-IN-19 (Compound 51) (80 mg/kg; i.p.; once) 在小鼠中抑制 CD69[1]。
BTK-IN-19 (5 mg/kg; p.o.) 在大鼠中体内清除率低，具有适中的口服利用度 (%F > 34) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/1 mice[1]
Dosage: 80 mg/kg
Administration: IP, once
Result: Demonstrated strong inhibition of CD69.
分子量

445.34

Formula

C21H22Cl2N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTK-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-191374240-01-3BtkBruton tyrosine kinaseB-cellPBMCInhibitorinhibitorinhibit

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产品名称：
BTK-IN-19
目录号：
HY-152212
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