2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK Apoptosis
  3. HDAC c-Met/HGFR Apoptosis
  4. c-Met/HDAC-IN-2

c-Met/HDAC-IN-2 是一种高效的 c-Met 和 HDAC 双重抑制剂，对 HDAC1 与 c-Met 的 IC50 分别为 18.49 nM 和 5.40 nM。c-Met/HDAC-IN-2 对几种癌细胞具有抗增殖活性。c-Met/HDAC-IN-2 能将 HCT-116 细胞周期阻滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。c-Met/HDAC-IN-2 可用于抗癌耐药研究。

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c-Met/HDAC-IN-2 Chemical Structure

c-Met/HDAC-IN-2 Chemical Structure

CAS No. : 2740495-53-6

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c-Met/HDAC-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

c-Met/HDAC-IN-2 is a highly potent c-Met and HDAC dual inhibitor with IC50s of 18.49 nM and 5.40 nM for HDAC1 and c-Met, respectively. c-Met/HDAC-IN-2 has antiproliferative activities against certain cancer cell lines. c-Met/HDAC-IN-2 can cause G2/M-phase arrest and induce apoptosis in HCT-116. c-Met/HDAC-IN-2 can be used for researching anti-cancer resistance[1].

IC50 & Target[1]

HDAC1

18.49 nM (IC50)

体外研究
(In Vitro)

c-Met/HDAC-IN-2 (compound 14X) (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) induces of cancer cell apoptosis in a dose-dependent manner[1].
c-Met/HDAC-IN-2 (0.2-5 μM; 48 hours) significantly causes G2/M-phase arrest in HCT-116 cells in a dose dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met/HDAC-IN-2 相关抗体:

Cell Proliferation Assay

Cell Line: HCT-116, MCF-7 and A549[1]
Concentration: 0-20 μM
Incubation Time: 72 hours
Result: Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC50s of 0.22 ± 0.09 μM, 1.59 ± 0.06 μM and 0.22 ± 0.04 μM, respectively.

Apoptosis Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: The percentage of apoptotic cells was 4.19%, 11.53% and 21.48% at 0.2 μM, 1.0 μM and 5.0 μM, respectively.

Cell Cycle Analysis

Cell Line: HTC-116[1]
Concentration: 0.2, 1 and 5 μM
Incubation Time: 48 hours
Result: Significantly caused G2/M-phase arrest in HCT-116 cells in a dose dependent manner.
分子量

623.66

Formula

C34H33N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

c-Met/HDAC-IN-2 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met/HDAC-IN-22740495-53-6HDACc-Met/HGFRApoptosisHistone deacetylasesAnticancerAntiproliferative activitiesHCT-116MCF-7A549Inhibitorinhibitorinhibit

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