2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. CA/MAO-B-IN-1

CA/MAO-B-IN-1 (Compound 78) 是人 CA 和 MAO-B 的双重抑制剂，IC50 分别为 8.8 和 7.0 nM。CA/MAO-B-IN-1 通过计算机模拟的人体口服吸收率为 71.9%。

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CA/MAO-B-IN-1 Chemical Structure

CA/MAO-B-IN-1 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CA/MAO-B-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction[1].

IC50 & Target

hCA VB

8.8 nM (IC50)

hCA VA

9.6 nM (IC50)

hCA II

41.1 nM (IC50)

hCA XII

196 nM (IC50)

hCA I

553.1 nM (IC50)

体外研究
(In Vitro)

CA/MAO-B-IN-1 (12.5-50 μM) 恢复 ROS 的水平，对 SH-SY5Y 细胞中 Aβ1-42 寡聚物诱导的神经毒性表现出神经和线粒体保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CA/MAO-B-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y
Concentration: 12.5-50 μM
Incubation Time: 24 h
Result: Improved cell viability in SH-SY5Y cells damaged by Aβ1-42.
分子量

345.37

Formula

C17H15NO5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CA/MAO-B-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CA/MAO-B-IN-1Carbonic AnhydraseCarbonate dehydrataseSH-SY5YAβ1-42Alzheimer’s diseaseInhibitorinhibitorinhibit

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目录号：
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