2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. CB2 receptor agonist 6

CB2 receptor agonist 6 (compound 70) 是一种 CB2R 激动剂，EC50 为162 nM。CB2 receptor agonist 6 对 CB1R 和 CB2R 的 IC50 值分别为 4.83 μM 和 0.88 μM。CB2 receptor agonist 6 是一种神经保护剂，可以用作神经系统疾病研究。

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CB2 receptor agonist 6 Chemical Structure

CB2 receptor agonist 6 Chemical Structure

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CB2 receptor agonist 6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease[1].

IC50 & Target

CB2R

 

体外研究
(In Vitro)

CB2 receptor agonist 6 (compound 70) (5 μM, 0/15/30/60 min) 在体外代谢稳定性研究中表现良好[1]。
CB2 receptor agonist 6 (5 μM, 0/0.5/1/1.5/2 h) 具有体外激活 CB2R 的活性，抑制人和小鼠的cAMP 表达[1]。
CB2 receptor agonist 6 (0.01-10 μM, 90 min) 在体外竞争结合实验中，与 CB1R 和 CB2R 的 Ki 值分别为 8.8 nM 和 0.89 nM，表现出对 CB2R 的选择性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 6 相关抗体:
体内研究
(In Vivo)

CB2 receptor agonist 6 (compound 70) (1/5/10 mg/kg, intraperitoneal injection, predetermined intervals 0.25/0.5/1/2/6/24 h) 可显著逆转东莨菪碱致健忘症小鼠模型的遗忘效果，同时不会影响正常小鼠的空间学习和记忆能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine-induced amnesia murine model[1]
Dosage: 0.1 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Showed neuroprotective effects on scopolamine induced cognitive function in male mice.
Did not affect spatial learning and memory processes in naïve mice.
分子量

370.42

Formula

C24H19FN2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CB2 receptor agonist 6 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2 receptor agonist 6Cannabinoid ReceptorAmnesia murine modelCannabinoid systemNeurodegenerative diseasesNeuroinflammationMALDI imaging analysisAlzheimer’s disease (AD)Pharmacokinetic propertiesInhibitorinhibitorinhibit

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