2. PI3K/Akt/mTOR
  3. mTOR
  4. CC214-1

CC214-1 是一种潜在有效的 mTOR 抑制剂，可诱导自噬 (autophagy)，IC50 为 0.002 μM。 CC214-1 被证明可作为体外工具化合物用于探索 mTOR 激酶生物学。 CC214-1 可用于胶质母细胞瘤研究。

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CC214-1 Chemical Structure

CC214-1 Chemical Structure

CAS No. : 1021920-32-0

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CC214-1 相关抗体

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CC214-1 is a potentially efficacious mTOR inhibitor that induces autophagy [1],with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTOR kinase biology. CC214-1 can be used for Glioblastoma study[2].

IC50 & Target [2]

mTOR

0.002 μM (IC50)

体外研究
(In Vitro)

CC214-1 (0, 0.1, 1, 2, 5, 10 μM, 8 h; 2 μM, 24 h) 与 rapamycin (HY-10219) 协同作用，抑制 mTORC1 信号传导和肿瘤细胞增殖[1]。
CC214-1 (2 μM, 24 h) 介导因 EGFRvIII 表达和 PTEN 缺失而导致胶质母细胞瘤细胞生长停滞的敏感性[1]。
CC214-1 (5 μM, 0-48 h) 将 LC3B-I 大量脂化为 LC3B-II 亚型，并诱导 GBM39 细胞自噬[1]。
CC214-1 对 mTOR 的 IC50 为 0.002 μM[2]。
CC214-1 (0-10 μM, 4days) 可有效抑制 T 细胞活化和 T 细胞活化标记物的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CC214-1 相关抗体:

Western Blot Analysis[1]

Cell Line: glioblastoma
Concentration: 0, 0.1, 1, 2, 5, 10 μM; 2 μM
Incubation Time: 8 h; 24 h
Result: Inhibited mTORC1 signaling in all glioblastoma cell lines tested, potently suppressing rapamycin-resistant 4E-BP1 and mTORC2 signaling.
Inhibited mTORC1-dependent 4E-BP1 and S6 phosphorylation in EGFRvIII-expressing glioblastoma cells, as well as blocked glioblastoma cells overexpressing wild-type EGFR.

Immunofluorescence[1]

Cell Line: glioblastoma
Concentration: 2 μM, 5 μM
Incubation Time: 4 h; 0, 4, 12, 24, 48 h
Result: Induced a transient expression of LC3B-II isoform and the conjugation of Atg12 to Atg5 indicative of the stimulation of the autophagy flux in U87EGFRvIII cell line.
Massively lipidated LC3B-I to LC3B-II subtype and induces autophagy in GBM39 cells.

Cell Cycle Analysis[3]

Cell Line: glioblastoma
Concentration: 0-10 μM
Incubation Time: 4 day
Result: Induced TEE cells in CD4+ and CD8+ T cell subsets.
分子量

391.43

Formula

C20H21N7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CC214-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC214-11021920-32-0mTORMammalian target of RapamycinGlioblastomacardiovascularautophagyInhibitorinhibitorinhibit

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HY-154910
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