2. Membrane Transporter/Ion Channel
  3. CFTR
  4. CFTR corrector 12

CFTR corrector 12 (compound 17C) 是一种双噻唑衍生物，用作CFTR校正剂。CFTR corrector 12 能够校正一些负责控制氯离子跨质膜运输的通道的折叠缺陷突变。CFTR corrector 12 恢复突变细胞中 α-肌聚糖 (α-SG) 含量。

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CFTR corrector 12 Chemical Structure

CFTR corrector 12 Chemical Structure

CAS No. : 958941-60-1

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CFTR corrector 12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells[1].

体外研究
(In Vitro)

CFTR corrector 12 (compound 17C) (15 μM; 72 h) 能够恢复 L31P/V247M α-SG 突变细胞中 α-肌聚糖含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CFTR corrector 12 相关抗体:
分子量

436.98

Formula

C19H21ClN4O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CFTR corrector 12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFTR corrector 12958941-60-1CFTR corrector12CFTR corrector-12CFTRCystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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CFTR corrector 12
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