2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Monoamine Oxidase Reactive Oxygen Species
  4. CHBO4

CHBO4 是一种强效的，可逆的，竞争性和选择性的 hMAO-B 抑制剂，在 CHBO 子系列中针对 hMAO-B 的 IC50 值为 0.031 μM， Ki 值为 0.010 ± 0.005 μM。CHBO4 通过清除细胞内活性氧 (ROS) 减少细胞损伤，可用于帕金森病 (PD) 的研究。

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CHBO4 Chemical Structure

CHBO4 Chemical Structure

CAS No. : 98991-32-3

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CHBO4 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. CHBO4 reduce cell damage by scavenging intracellular reactive oxygen species (ROS). CHBO4 can be used for Parkinson's Disease (PD) research[1].

IC50 & Target[1].

hMAO-B

0.031 μM (IC50)

hMAO-B

0.010 μM (Ki)

体外研究
(In Vitro)

CHBO4 (10-500 µg/mL, 48 小时) 在 Vero 细胞中具有生物安全性[1]。
CHBO4 (128.8 µg/mL, 10 分钟) 能减少 Vero 细胞中 ROS 生成量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHBO4 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Vero cells
Concentration: 10-500 µg/mL
Incubation Time: 48 h
Result: Reduced cell viability percentage with the IC50 value of 128.8 µg/mL
Decreased cellular density, cellular shrinkage, and blebbing exposed to concentrations (100-300 µg/mL) in Vero cells
分子量

305.14

Formula

C15H10BrFO
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHBO4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHBO498991-32-3CHBO 4CHBO-4Monoamine OxidaseReactive Oxygen SpeciesMAOchalcone-based oximesHMAO-B inhibitionreversibilitycytotoxicityROS assaymolecular dynamicsParkinson'sneurological disorderInhibitorinhibitorinhibit

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