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  3. Chitin synthase inhibitor 11

Chitin synthase inhibitor 11 是一种几丁质合酶 (CHS) 抑制剂。Chitin synthase inhibitor 11 显示出优异的 CHS 抑制活性,IC50 值为 0.10 mM。Chitin synthase inhibitor 11 具有广谱体外抑菌活性。Chitin synthase inhibitor 11 可用于侵袭性真菌感染 (IFIs) 的研究。

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Chitin synthase inhibitor 11 Chemical Structure

Chitin synthase inhibitor 11 Chemical Structure

CAS No. : 2725075-04-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs)[1].

IC50 & Target

IC50: 0.10 mM (chitin synthase)[1]
MIC: 128 μg/mL (C. albicans); 42.67 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)[1]

体外研究
(In Vitro)

Chitin synthase inhibitor 11 (compound 9s) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC50 value of 0.10 mM[1].
Chitin synthase inhibitor 11 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 128μg/mL, 42.67 μg/mL, 64 μg/mL and 64 μg/mL, respectively[1].
Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

496.47

Formula

C24H24N4O8

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献

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Chitin synthase inhibitor 11
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HY-151421
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