Cloxacepride 

Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity^[1][2].

Cloxacepride (10-50 μM) 对 Compound 48/80 (HY-115768) 诱导的大鼠肠系膜肥大细胞释放组胺和血清素有抑制作用。IC₅₀ 为 21 μM (组胺)和 19 μM (血清素)^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cloxacepride 的口服 ED₅₀ 值为 46-49 mg/kg，与茶碱 (Theophylline, HY-B0809) 和静脉注射 2 mg/kg 色甘酸二钠 (DSCG) 后立即激发相当^[1]。
在抗原攻击前 15 或 60 分钟口服给药时，Cloxacepride 具有抗 PCA 活性^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

468.37

C₂₂H₂₇Cl₂N₃O₄

65569-29-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Metz G, et al. Cloxacepride and related compounds: a new series of orally active antiallergic compounds. J Med Chem. 1983 Jul;26(7):1065-70.  [Content Brief]

  [2]. Gigl G, et al. Calmodulin antagonism: a pharmacological approach for the inhibition of mediator release from mast cells. Cell Calcium. 1987 Oct;8(5):327-44.  [Content Brief]

  [3]. Friedrich G, et al. Inhibitory effect of cloxacepride on compound 48/80-induced histamine and serotonin release from rat mast cells. Arch Int Pharmacodyn Ther. 1984 Feb;267(2):264-8.  [Content Brief]