2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. CNBCA

CNBCA 是一种有效的、选择性的、竞争性的 SHP2 酶抑制剂，IC50 为 0.87 μM。CNBCA 结合全长 SHP2 并抑制其酶活性。CNBCA 抑制 Akt 和 ERK1/2 的磷酸化，抑制 BT474 和 MDA-MB468 细胞的生长。CNBCA 可用于乳腺癌的研究。

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CNBCA Chemical Structure

CNBCA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CNBCA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1].

IC50 & Target

0.87 μM (SHP2)[1]
体外研究
(In Vitro)

CNBCA (0.25, 0.50, 1,2 μM, 48 h) 抑制 SHP2 介导的 BT474 和 MDA-MB468 细胞中 Akt 和ERK1/2 的激活，IC50 约为 1.0 μM[1]。
CNBCA (500 nM, 24-72 h) 抑制 BT47 4和 MDA-MB468 细胞的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CNBCA 相关抗体:

Western Blot Analysis[1]

Cell Line: BT474 and MDA-MB468 cells
Concentration: 0.25, 0.50, 1, 2 μM
Incubation Time: 48 h
Result: Inhibited SHP2 mediated Akt and ERK1/2 activation.
分子量

426.55

Formula

C26H34O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CNBCA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CNBCASHP2Src homology phosphatase 2PTPN11breast cancerpAktpERK1/2BT474MDA-MB468Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-155098
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