2. Immunology/Inflammation
  3. Tim3
  4. Cobolimab

Cobolimab  (Synonyms: TSR-022; GSK4069889)

目录号: HY-P99827 纯度: ≥95.0%
COA

摩尔计算器

Cobolimab (TSR-022) 是一种 TIM-3 单克隆抗体。Cobolimab 介导 TIM-3 的内化，IC50 值为 0.4464 nM。Cobolimab 在实体瘤、非小细胞肺癌 (NSCLC) 中有潜在应用。

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Cobolimab Chemical Structure

Cobolimab Chemical Structure

CAS No. : 2022215-65-0

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5 mg ￥7800
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Cobolimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC)[1][2][3].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Cobolimab (0.0001-10 nM；3 d) 在预激活 T 细胞中以剂量依赖性方式促进 TIM-3 内化，IC50 值为 0.4464 nM[3]。
Cobolimab (20 µg/mL；24 h) 通过抑制 TIM-3 显著增加了 CD8+ T 细胞含量[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cobolimab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Cobolimab 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Cobolimab2022215-65-0TSR-022 GSK4069889TSR022TSR 022GSK4069889GSK 4069889GSK-4069889Tim3T-Cell Immunoglobulin and Mucin Containing Protein-3CD366Pre-activated T cellsCD8+ T cellNSCLCSolid tumorsInhibitorinhibitorinhibit

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