2. Cell Cycle/DNA Damage
  3. CDK
  4. Crozbaciclib fumarate

Crozbaciclib fumarate 是 CDK4/6 的抑制剂，IC50 值分别为 3 和 1 nM。

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Crozbaciclib fumarate Chemical Structure

Crozbaciclib fumarate Chemical Structure

CAS No. : 2567494-39-5

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Other Forms of Crozbaciclib fumarate:

Crozbaciclib fumarate 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Crozbaciclib fumarate is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively.

IC50 & Target

IC50: 3 nM (CDK4), 1 nM (CDK6)[1]
体外研究
(In Vitro)

Crozbaciclib fumarate 是一种有效的抗增殖剂，可将 U87MG 细胞系完全抑制在 G1 期（抗增殖试验中的 IC50=15.3 ± 2.9 nM）。 Crozbaciclib fumarate (13.72 nM; 24 h)显着增加 U87MG 细胞中 G1 期细胞的百分比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Crozbaciclib fumarate 相关抗体:
体内研究
(In Vivo)

Crozbaciclib fumarate (3.125-50 mg/kg) 在多形性胶质母细胞瘤原位异种移植小鼠模型中具有 62% 至 99% 的肿瘤生长抑制值。 而 Crozbaciclib fumarate 导致体重减轻不明显。 在 50 mg/kg[1] 的剂量下，Crozbaciclib fumarate 显着延长了 162% 的小鼠中载体处理动物的平均存活时间，显着延长了寿命。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

604.65

Formula

C32H34F2N6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Crozbaciclib fumarate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crozbaciclib2567494-39-5CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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产品名称：
Crozbaciclib fumarate
目录号：
HY-112280A
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