2. NF-κB
  3. NF-κB
  4. CTP-NBD

CTP-NBD 是一种细胞渗透性特异 NFκB 抑制剂。CTP-NBD 可用于结肠炎的研究。

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Custom Peptide Synthesis

CTP-NBD Chemical Structure

CTP-NBD Chemical Structure

CAS No. : 1268513-27-4

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CTP-NBD 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CTP-NBD is a cell permeable specific NFκB peptide inhibitor. CTP-NBD could be used in colitis study[1][2]

体外研究
(In Vitro)

CTP-NBD (200 μM, 6 h) 在 HCT116 细胞中可抑制 TNF-α 诱导的荧光素酶活性[1].
CTP-NBD (200 μM, 6 h) 在 RAW264.7 细胞中可抑制 IL-8, INOS 和 COX-2 的表达[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CTP-NBD 相关抗体:

Immunofluorescence[1]

Cell Line: HCT116
Concentration: 200 μM
Incubation Time: 6 h
Result: Inhibited the luciferase activity induced by TNF-α.

Western Blot Analysis[1]

Cell Line: RAW264.7
Concentration: 200 μM
Incubation Time: 6 h
Result: Inhibited the express of INOS and COX-2 protein.
体内研究
(In Vivo)

CTP-NBD 在结肠炎大鼠模型中不能有效降低炎症，但改造后的 Colon-targeted CTP-NBD 具有口服活性，且可以降低结肠炎大鼠模型炎症[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2805.12

Formula

C121H194N46O32
CAS 号
Sequence

Tyr-Gly-Arg-Arg-Ala-Arg-Arg-Arg-Ala-Arg-Arg-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
Sequence Shortening

YGRRARRRARRTALDWSWLQTE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CTP-NBD 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CTP-NBD1268513-27-4NF-κBNuclear factor-κBNuclear factor-kappaBCOX-2InhibitorNFκBHCT116RAW264.7Inflammatory bowel disease (IBD)inhibitorinhibit

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目录号：
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