2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CXCR HIV
  4. CXCR4 antagonist 7

CXCR4 antagonist 7 (Compound PARA-B) 是一种 CXCR4 拮抗剂，IC50 为 9.3 nM。CXCR4 antagonist 7 可用于 HIV 感染、炎症性疾病、癌症和 WHIM 综合征的研究。

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CXCR4 antagonist 7 Chemical Structure

CXCR4 antagonist 7 Chemical Structure

CAS No. : 1185451-72-2

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CXCR4 antagonist 7 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXCR4 antagonist 7 (Compound PARA-B) is a CXCR4 antagonist with the IC50 of 9.3 nM. CXCR4 antagonist 7 can be used for the research of HIV infection, inflammatory diseases, cancer, and WHIM syndrome[1].

IC50 & Target

CXCR4/CXCL12

9.3 nM (IC50)

体外研究
(In Vitro)

CXCR4 antagonist 7 (PARA-B, 10 nM-1 μM, 20 h) inhibits CXCL12-induced GH4C1 cell proliferation with an IC50 value of 9.3 nM[1].
CXCR4 antagonist 7 (1 μM, 12 h) inhibits CXCL12-dependent GH4C1 cell migration with inhibition rate of 50%[1].
CXCR4 antagonist 7 (50 nM, 30 min) reduces ERK1/2 phosphorylation induced by CXCL12[1].
CXCR4 antagonist 7 (50 nM-1 μM, 30 min) acts via CXCR4 antagonism to revert CXCL12 induction of GH4C1 proliferation and migration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CXCR4 antagonist 7 相关抗体:

Cell Viability Assay[1]

Cell Line: GH4C1 cell (48 h of serum deprivation)
Concentration: 1 μM
Incubation Time: 24 h
Result: Had no effect on cell viability of GH4C1 cell.

Cell Proliferation Assay[1]

Cell Line: GH4C1 cell ( FBS-starved GH4C1 cells treated with CXCL12 (25 nM) for 12 h)
Concentration: 10 nM-1 μM
Incubation Time: 20 h, 24 h
Result: Inhibited proliferation of multiple cancer cell lines with IC50 value ranging from 1.08 to 3.45 μM, and had no effect on cell viability of GH4C1cell.

Cell Migration Assay [1]

Cell Line: GH4C1 and GH4A11 cells (FBS-starved cells treated with CXCL12 (25 nM) for 48 h)
Concentration: 50 nM-1 μM
Incubation Time: 12 h for GH4C1, 30 min for GH4A11
Result: Reduced the number of migrating GH4C1 cells significantly, had no effect on GH4A11 cell (CRISPR-CAS9, reduction in CXCR4 mRNA) migration.

Western Blot Analysis[1]

Cell Line: GH4C1 cell (FBS-starved cells treated with CXCL12 (25 nM) for 15 min)
Concentration: 50 nM
Incubation Time: 30 min
Result: Reduced ERK1/2 phosphorylation induced by CXCL12.
分子量

315.33

Formula

C15H17N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CXCR4 antagonist 7 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR4 antagonist 71185451-72-2CXCRHIVCXC chemokine receptorsC-X-C motif chemokine receptorsHuman immunodeficiency virusCXCR4 antagonistHIV infectioninflammatory diseasescancerWHIM syndromeHydantoin alkaloidParazoanthineInhibitorinhibitorinhibit

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