2. PI3K/Akt/mTOR Stem Cell/Wnt MAPK/ERK Pathway
  3. PI3K ERK
  4. CXJ-2

CXJ-2 是一种环状肽，对弹性蛋白衍生肽 (EDP) 表现出中等亲和力。 CXJ-2 表现出抑制 PI3K/ERK 通路并减少肝星状细胞增殖和迁移的有效活性。 CXJ-2 具有强大的抗纤维化作用。

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Custom Peptide Synthesis

CXJ-2 Chemical Structure

CXJ-2 Chemical Structure

CAS No. : 2919976-92-2

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CXJ-2 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXJ-2 is a cyclic peptide, and exhibits moderate affinity toward elastin derived peptides (EDPs). CXJ-2 exhibits potent activities to inhibit the PI3K/ERK pathway and decrease hepatic stellate cell proliferation and migration. CXJ-2 possesses potent antifibrotic efficacy[1].

IC50 & Target

PI3K

 

ERK

 

体外研究
(In Vitro)

CXJ-2 (10 μM , 24 h) 以剂量依赖性方式降低 LX2 细胞中的 α-SMA 表达[1]。
CXJ-2 (10 μM , 24 h) 表现出优异的抑制 LX2 细胞增殖的活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CXJ-2 相关抗体:
体内研究
(In Vivo)

CXJ-2 (150 μg/kg，腹腔注射，每日一次，持续 3 周)可显著减轻小鼠肝纤维化[1]。
CXJ-2 (0.1 mg/kg，皮下注射，单剂量)显示出良好的药代动力学特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks, 20-24 g, CCl4-induced liver fibrosis model)[1]
Dosage: 150 μg/kg
Administration: IP, daily, for 3 weeks
Result: Significantly decreased the HYP (hydroxyproline) content in liver tissue. Decreased collagen deposition. Remarkably diminished hepatic fibrosis.
Animal Model: Sprague-Dawley rats[1]
Dosage: 0.1 mg/kg
Administration: SC, single dose (Pharmacokinetic Analysis)
Result: Showed favorable pharmacokinetic properties (Tmax=0.33 h, T1/2=0.46 h), and displayed enhanced clearance profiles. Displayed significantly higher serum stability with a half-life longer than 36 h.
分子量

1310.37

Formula

C55H87N15O22
CAS 号
Sequence

cyclo(Val-{Iva}-Gly-Ser-Pro-Ser-Ala-Gln-Glu-Glu-Ala-Ser-Pro-Ala)
Sequence Shortening

cyclo(V-{Iva}-GSPSAQEEASPA)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CXJ-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXJ-22919976-92-2CXJ2CXJ 2PI3KERKPhosphoinositide 3-kinaseExtracellular signal regulated kinasesLiver fibrosiscyclic peptideLX2 cellshydroxyprolineα-SMAcollagen depositionInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149205
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