Cytostatin sodium 

Cytostatin sodium is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin sodium exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin sodium can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin sodium belongs to the family of natural product fosriecin^[1][2][3][4].

IC50: 210 nM (PP2A)^[1].

450.44

C₂₁H₃₂NaO₇P

457070-06-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128(51):16720-16732.  [Content Brief]

  [2]. Kawada M, et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999;1452(2):209-217.  [Content Brief]

  [3]. Kawada M, et al. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res. 1999;90(2):219-225.  [Content Brief]

  [4]. Bialy L, et al. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chemistry. 2004;10(11):2759-2780.  [Content Brief]