2. PI3K/Akt/mTOR NF-κB
  3. NF-κB PIKfyve IKK
  4. DC-SX029

DC-SX029 是一种有效的 SNX10 蛋白质-蛋白质相互作用 (PPI) 抑制剂，通过表面等离子共振 (SPR) 实验获得 KD 约为 0.935 μM。DC-SX029 阻断 SNX10-PIKfyve 相互作用，从而减少 TBK1/c-Rel 信号传导激活。DC-SX029不影响SNX10的蛋白水平。DC-SX029 具有用于炎症性肠病 (IBD) 研究的潜力。

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DC-SX029 Chemical Structure

DC-SX029 Chemical Structure

CAS No. : 300713-88-6

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DC-SX029 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 IKK 亚型特异性产品:

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with an estimated KD constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research[1].

分子量

398.35

Formula

C14H17F3N2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DC-SX029 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC-SX029300713-88-6NF-κBPIKfyveIKKNuclear factor-κBNuclear factor-kappaBFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1IκB kinaseI kappa B kinaseSNX10PPIsurface plasmon resonanceSPRSNX10-PIKfyveTBK1/c-Relinflammatory bowel diseaseIBDInhibitorinhibitorinhibit

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目录号：
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