2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DL-AP5 sodium

DL-AP5 sodium  (Synonyms: 2-APV sodium; DL-2-Amino-5-phosphonovaleric acid sodium)

目录号: HY-100714C
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摩尔计算器

DL-AP5 (2-APV) sodium 是一种竞争性的 NMDA (N-methyl-D-aspartate) 受体拮抗剂。DL-AP5 sodium 表现出明显的镇痛活性。DL-AP5 sodium 可特异性阻断兔视网膜的通道。

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DL-AP5 sodium Chemical Structure

DL-AP5 sodium Chemical Structure

CAS No. : 1303993-72-7

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DL-AP5 sodium 的其他形式现货产品:

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DL-AP5 sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DL-AP5 (2-APV) sodium is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 sodium shows significantly antinociceptive activity. DL-AP5 sodium specifically blocks on channels in the rabbit retina[1][2][3].

IC50 & Target

NMDA Receptor

 

体外研究
(In Vitro)

DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels[5].
DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DL-AP5 sodium 相关抗体:
体内研究
(In Vivo)

DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA[3].
DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption[4].
DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-230 g)[3]
Dosage: 1, 3.2 and 10 μg/rat
Administration: Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result: Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration: Intracerebroventricular injection
Result: Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
Animal Model: Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)[4]
Dosage: 5 nmol
Administration: Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result: Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
分子量

219.11

Formula

C5H11NNaO5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DL-AP5 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-AP51303993-72-72-APVDL-2-Amino-5-phosphonovaleric acidiGluRIonotropic glutamate receptorsAntinociceptive activityTonic painGanglion cellsRetinaArc/Arg3.1Glutamate receptorInhibitorinhibitorinhibit

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