2. Inhibitory Antibodies
  3. Elarekibep

Elarekibep  (Synonyms: PRS-060; AZD1402)

目录号: HY-P99935 纯度: 98.86%
COA

摩尔计算器

Elarekibep (PRS-060) (AZD1402) 是一种高亲和力、缓慢解离的长效 IL-4Ra 完全拮抗剂。Elarekibep 可用于 T2 内型哮喘的研究。

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Elarekibep Chemical Structure

Elarekibep Chemical Structure

CAS No. : 2485020-60-6

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1 mg ￥6500
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Elarekibep 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elarekibep (PRS-060) (AZD1402) is a high affinity, slowly dissociating, long-acting full antagonist of IL-4Ra. Elarekibep can be used for the research of T2 endotype asthma[1].

体外研究
(In Vitro)

Elarekibep (PRS-060) (0-10 µM) 抑制 IL-4 或 IL-13 诱导的 STAT-6 磷酸化，IC50 值分别为 0.12 nM 和 0.10 nM[1]。
PRS-060 (0-10 µM) 抑制 hIL-4 或 hIL-13 诱导的 TF-1 细胞增殖，IC50 值分别为 0.87 nM 和 0.92 nM[1]。
PRS-060 (0-10 µM) 抑制 hIL-13 诱导的人上皮细胞粘液转分化，IC50 值为 0.3 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Elarekibep 相关抗体:
体内研究
(In Vivo)

PRS-060（气管内滴注；2、10、50 µg）抑制人源化小鼠肺中 IL-13 诱导的 eotaxin-1 表达和卵清蛋白诱导的急性过敏性炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-humanized mouse model[1]
Dosage: 2, 10, 50 µg/mouse
Administration: Intratracheal instillation (i.t)
Result: Strongly suppressed acute allergic inflammation indices in triple humanized mice.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.86%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elarekibep2485020-60-6PRS-060 AZD1402PRS060PRS 060AZD1402AZD 1402AZD-1402OthersIL-4RaT2 endotype asthmanticalin protein therapeuticInhibitorinhibitorinhibit

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