2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis Autophagy Anti-infection Others
  3. Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye
  4. Elsinochrome A

Elsinochrome A 是一种苝醌光敏剂，在光激发下可产生活性氧 (reactive oxygen species)，诱导细胞凋亡 (Apoptosis) 和自噬 (Autophagy)。Elsinochrome A 还表现出针对白色念珠菌的抗真菌活性，通过光动力抗菌化疗 (PACT) 可去除白色念珠菌的生物膜。Elsinochrome A 可用于光动力疗法 (PDT) 的研究 (Ex: 460 nm)。

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Elsinochrome A Chemical Structure

Elsinochrome A Chemical Structure

CAS No. : 24568-67-0

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Elsinochrome A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm)[1][2].

体外研究
(In Vitro)

Elsinochrome A (0-3 μM，5 min) 可降低 B16 细胞的存活率、诱导细胞内 ROS 产生、诱导自噬体形成并在光照下诱导细胞凋亡[1]。
Elsinochrome A (0.3-3 μM, 5 min) 定位于 B16 细胞的线粒体[1]。
Elsinochrome A (0-32 μg/mL，24 或 48 小时) 在光照射时显示出针对白色念珠菌的抗真菌活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Elsinochrome A 相关抗体:

RT-PCR[1]

Cell Line: B16 cells
Concentration: 0.3-3 μM
Incubation Time: 5 min
Result: Decreased expression of atg2, atg9 and atg10 genes.
Increased expression of caspase2, caspase9 and tnfgenes.

Western Blot Analysis[1]

Cell Line: B16 cells
Concentration: 0.3-3 μM
Incubation Time: 5 min
Result: Decreased expression of Atg5 and CytC protein.
分子量

544.51

Formula

C30H24O10
CAS 号
结构分类
初始来源

Graphis elongata Zenker
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Elsinochrome A 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Elsinochrome A24568-67-0Reactive Oxygen SpeciesApoptosisAutophagyFungalFluorescent DyephototoxicityPDTROSphotosensitizermelanomaInhibitorinhibitorinhibit

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