2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. Enoticumab

Enoticumab  (Synonyms: REGN421)

目录号: HY-P99925

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Enoticumab (REGN421，SAR153192 ) 是靶向人类 Dll4 的 IgG1κ 抗体。DLL4 是 Notch 信号通路的配体，通过巨胞饮依赖性长链脂肪酸摄取的非转录调节来调节脂肪酸摄取。Enoticumab 在卵巢异种移植模型中具体体内活性。EGN421（2.5mg/kg，每周一次）可分别在小鼠皮下 TOV-112D 或腹膜内 A2780 人肿瘤异种移植模型中，导致 86% 和 83% 的肿瘤生长抑制。

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Enoticumab Chemical Structure

Enoticumab Chemical Structure

CAS No. : 1192578-27-0

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Enoticumab 相关抗体

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生物活性

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively[1].

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Keywords:

Enoticumab1192578-27-0REGN421REGN 421REGN-421NotchTOV-112DA2780Inhibitorinhibitorinhibit

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