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Etiprednol dicloacetate  (Synonyms: BNP 166; Etiprednol dichloroacetate)

目录号: HY-106215
产品使用指南

Etiprednol dicloacetate (BNP 166) 是一种抗炎剂。Etiprednol dicloacetate 抑制嗜酸性粒细胞的积累。Etiprednol dicloacetate 可用于哮喘等炎症性气管疾病的研究。

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Etiprednol dicloacetate Chemical Structure

Etiprednol dicloacetate Chemical Structure

CAS No. : 199331-40-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma[1][2].

体外研究
(In Vitro)

Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Etiprednol dicloacetate (0-100 μg/kg, intranasal inhalation) attenuates peribronchial eosinophilia in the lung of the allergen sensitized and challenged rats[1].
Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration)[3].
Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Allergen sensitized and challenged Brown Norway rats[1]
Dosage: 0.1, 1, 10, and 100 μg/kg
Administration: Intranasal inhalation
Result: Decreased the number of eosinophils at the perivascular area of the lung tissue.
Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.
Clinical Trial
分子量

485.40

Formula

C24H30Cl2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Etiprednol dicloacetate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Etiprednol dicloacetate
目录号:
HY-106215
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