Forigerimod TFA  (Synonyms: IPP-201101 TFA)

Forigerimod TFA (IPP-201101 TFA) is a CD4 T-cell modulator. Forigerimod TFA is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod TFA can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) ^[1][2][3][4].

Forigerimod TFA (P140) (i.v.; 100 μg in 100 μL saline per mouse) directly acts on chaperone-mediated autophagy, rescues MRL/lpr mice from cellular infiltration and autophagy defects occurring in salivary glands^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₁₁₇H₁₈₁N₃₄O₃₂PS.xC₂HF₃O₂

固体

White to off-white

RIHMVYSKR-{pSer}-GKPRGYAFIEY (TFA)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Aikaterini Thanou, et al. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys.  [Content Brief]

  [2]. Sean Robinson, et al. Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus. Front Immunol. 2021 Jul 16;12:654701.  [Content Brief]

  [3]. Robert Zimmer, et al. Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial. Ann Rheum Dis. 2013 Nov;72(11):1830-5.  [Content Brief]

  [4]. Baihui Li, et al. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. J Autoimmun. 2018 Jun;90:132-145.  [Content Brief]