2. Anti-infection
  3. Reverse Transcriptase HIV
  4. Fosalvudine tidoxil

Fosalvudine tidoxil 是一种具有口服活性的核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂 (NRTI)。Fosalvudine tidoxil 是由 Alovudine (HY-B1516) 衍生的前药。Fosalvudine tidoxil 毒性小于 Alovudine，可用于 HIV-1 感染的研究。

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Fosalvudine tidoxil Chemical Structure

Fosalvudine tidoxil Chemical Structure

CAS No. : 763903-67-9

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Fosalvudine tidoxil 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection[1].

IC50 & Target

Nucleoside reverse transcriptase[1]
体内研究
(In Vivo)

Fosalvudine tidoxil (15-100 mg/kg/day; oral; 8 weeks) 对大鼠产生显著的线粒体肝毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 15, 40, or 100 mg/kg/day
Administration: Oral gavage, 8 weeks
Result: Induced significant mtDNA depletion. At doses of 15, 40, and 100 mg/kg, the mean hepatic mtDNA values were 62, 64, and 47% of control values, respectively.
分子量

722.93

Formula

C35H64FN2O8PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fosalvudine tidoxil 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Fosalvudine tidoxil763903-67-9Reverse TranscriptaseHIVHuman immunodeficiency virusmitochondrial hepatotoxicitymtDNASprague-Dawley ratsInhibitorinhibitorinhibit

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