2. Gene
  3. SUB1 - SUB1 regulator of transcription Gene

SUB1 - SUB1 regulator of transcription Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SUB1 转录调节因子

种属: Homo sapiens

同用名: P15; PC4; p14

基因 ID: 10923 | 基因类型: protein coding

关于 SUB1

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,585,557-32,604,079 (from NCBI)

This gene has 13 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in brain (RPKM 41.5), fat (RPKM 34.4) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性；单链 DNA 结合活性；和转录共激活因子活性。参与 DNA 代谢过程的负调控和 RNA 聚合酶 II 的转录调控。位于核仁和核质中。转录调节复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; single-stranded DNA binding activity; and transcription coactivator activity. Involved in negative regulation of DNA metabolic process and regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SUB1 基因产物(1)

mRNA Protein Name
NM_006713.4 NP_006704.3 activated RNA polymerase II transcriptional coactivator p15

SUB1 蛋白结构

PC4

PC4: Transcriptional Coactivator p15 (PC4) (63 - 116)

  • 0
  • 100
  • 127 a.a.
蛋白主名 其他名称

activated RNA polymerase II transcriptional coactivator p15

SUB1 homolog, transcriptional regulator

重组 SUB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74650 PC4/SUB1 Protein, Human (His) P53999 (M1-L127) ≥95%

关联疾病

疾病名称 别名
Dyskeratosis Congenita, Autosomal Recessive 5

Dyskeratosis Congenita, Autosomal Dominant, 4

DKCB5

Autosomal Dominant Dyskeratosis Congenita 4

DKCA4

Autosomal Recessive Dyskeratosis Congenita 5

Dyskeratosis Congenita, Autosomal Recessive, 5

Dyskeratosis Congenita, Autosomal Dominant 4

Dyskeratosis Congenita, Autosomal Recessive, Type 5
Tinea Manuum

Tinea Manus

Dermatophytosis Of Hand
Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

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纯度 Phase
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HY-15025S2 Sildenafil-d3-1 99.47% 否
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HY-B0228S8 Adenosine-d1-2 99.72% 否
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HY-W013504S 1-Bromo-4-(trifluoromethyl)benzene-d4 / 否
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HY-B0389S7 D-Glucose-d1-3 99.90% 否
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HY-130462S 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d31 ≥99.0% 否
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HY-14648S5 Dexamethasone-d3-1 98.02% 否
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HY-109541S2 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d9 ≥99.0% 否
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HY-15029S1 (±)-Naproxen-d3-1 / 否
HY-10003S Alfacalcidol-d7 Activator / 否
HY-100441S1 Treprostinil-13C2,d1 Inhibitor / 否
HY-10585S4 Valproic acid-d4-1 / 否
HY-10846S1 Delamanid-d4-1 / 否
HY-108506S2 Licarbazepine-d4-1 Inhibitor / 否
HY-109506S3 DPPC-d9-1 / 否
HY-109541S 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d58 / 否
HY-109541S1 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d4 / 否
HY-109541S3 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d13 / 否
HY-109541S4 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d63 / 否
HY-109541S5 1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d67 / 否
HY-112530S 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 / 否
HY-113136S 1-Methylguanosine-d3 / 否
HY-113424AS 1,2-Dioleoyl-sn-glycero-3-phosphocholine-d9 / 否
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HY-114041S1 Resolvin E1-d4-1 / 否
HY-122426S1 1-Bromoundecane-d3 / 否
HY-122426S2 1-Bromoundecane-d4 / 否
HY-12650S Mirogabalin-13C2,d1 (Mixture of Diastereomers) / 否
HY-12987S2 Pimozide-d4-1 Inhibitor / 否
HY-130462S1 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-d82 / 否
HY-135810S1 Cletoquine-d4-1 Inhibitor / 否
HY-13593S1 Chlorambucil-d8-1 / 否
HY-14281S2 Trilostane-d3-1 / 否
HY-14648S1 Dexamethasone-d5-1 / 否
HY-14956S1 Nemonoxacin-d3-1 Inhibitor / 否
HY-152070S1 Demethylmaprotiline-d2-1 / 否
HY-15592S2 Cabotegravir-d3-1 Inhibitor / 否
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HY-15917S1 DL-dithiothreitol-d10-1 / 否
HY-17430S1 Amprenavir-d4-1 Inhibitor / 否
HY-18341S4 L-Thyroxine-13C6-1 / 否
HY-19696S2 Tauroursodeoxycholate-d4-1 Inhibitor / 否
HY-23506S 1-Aminoimidazolidine-2,4-dione-13C3 / 否
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HY-41681S 6-Chloro-1-hexanol-d6 / 否
HY-41700S2 D-Alanine-d1 / 否
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HY-79779S1 1-Bromo-4-(bromomethyl)benzene-d4 / 否
HY-90006S 5-Fluorouracil-d1 / 否
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HY-B0113S1 Omeprazole-d3-1 95.09% 否
HY-B0114S1 Oxcarbazepine-d4-1 / 否
HY-B0141S6 Estradiol-d2-1 Agonist / 否
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HY-B0158S4 Cytidine-d1 / 否
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HY-B0389S23 D-Glucose-d2-1 / 否
HY-B0389S25 D-Glucose-13C,d1 / 否
HY-B0389S3 D-Glucose-d1-1 / 否
HY-B0389S4 D-Glucose-d1-2 / 否
HY-B0400S7 D-Sorbitol-d1-2 / 否
HY-B0400S8 D-Sorbitol-d2-1 / 否
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HY-B0402S1 Amantadine-d6 98.10% 否
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HY-B0456S1 Riboflavin-5-Phosphate-13C4,15N2-1 / 否
HY-B0479S1 Thiamphenicol-d3-1 / 否
HY-B0561S2 Spironolactone-d3-1 / 否
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HY-B0896S1 Triacetin-d5 Inhibitor / 否
HY-B0901S1 Bromperidol-d4-1 Inhibitor / 否
HY-B1411S1 i-Inositol-d1 / 否
HY-B1659S3 Glycerol-d1 / 否
HY-B1716S1 L-5-Hydroxytryptophan-d3-1 / 否
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HY-N0210S12 D-Galactose-13C,d1 / 否
HY-N0210S5 D-Galactose-d1 / 否
HY-N0210S6 D-Galactose-d1-1 / 否
HY-N0210S7 D-Galactose-d1-2 / 否
HY-N0210S8 D-Galactose-d1-3 / 否
HY-N0215S13 L-Phenylalanine-d1 Antagonist / 否
HY-N0378S5 D-Mannitol-d1 / 否
HY-N0384S4 Homovanillic acid-d3-1 / 否
HY-N0537S12 Xylose-d1-3 / 否
HY-N0537S13 Xylose-d1-4 / 否
HY-N1380S4 Guaiacol-d4-1 / 否
HY-N1429S2 Taurochenodeoxycholic acid-d4-1 sodium Inducer / 否
HY-N7092S18 D-Fructose-d2-1 / 否
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HY-W016577S3 1-Bromoheptane-d7 / 否
HY-W016577S4 1-Bromoheptane-d1 / 否
HY-W016931S 1-Bromo-4-chlorobutane-d8 / 否
HY-W017554S 1-Chloro-2-methoxybenzene-d3 / 否
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HY-W032015S3 1-Bromooctane-d4 / 否
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HY-W040193S2 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79 / 否
HY-W040193S3 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 / 否
HY-W040193S5 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 / 否
HY-W040193S6 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d13 / 否
HY-W048482S rU Phosphoramidite-13C2,d1 / 否
HY-W050145S Levoglucosan-d7 / 否
HY-W050145S2 Levoglucosan-13C6 / 否
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HY-W087024S 1-Phenylpentane-d5 / 否
HY-W094751S 1-Pyrenamin-d9 / 否
HY-W097453S2 6-(Methylthio)purine-d3-1 / 否
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HY-W099504S2 1-Heptanol-d1 / 否
HY-W099521S 1-Chlorooctane-d17 / 否
HY-W101642S 1,3-Diisopropylbenzene-d18 / 否
HY-W105111S 1-Bromo-2,3,5-trichlorobenzene-d2 / 否
HY-W130478S 1-Phenylhexane-d5 / 否
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HY-W242724 1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8 / 否
HY-W711733 1-Bromopropane-d7 / 否
HY-W768340 Sucrose-13C6-1 / 否
HY-W865379 (S)-Avadomide-d1 / 否
HY-Y0093S NSC 5416-d14 / 否
HY-Y0219S 1,2,4-Triazole-13C2,15N3 / 否
HY-Y0219S1 1,2,4-Triazole-d3 / 否
HY-Y0531S 1-Adamantanol-d15 / 否
HY-Y0566S 1,4-Diazabicyclo[2.2.2]octane-d12 / 否
HY-Y0727S 1,5-Dibromopentane-d4 / 否
HY-Y0727S1 1,5-Dibromopentane-d10 / 否
HY-Y0860S 1,6-Dibromo-n-hexane-d12 / 否
HY-Y0921S (±)-1,2-Propanediol-d8 / 否
HY-Y0921S1 (±)-1,2-Propanediol-d2 / 否
HY-Y1004S3 1-Decanol-d5 / 否
HY-Y1004S4 1-Decanol-d4 / 否
HY-Y1039S 1-Stearoyl-rac-glycerol-d40 / 否
HY-Y1044S 1,5-Dihydroxypentane-d10 / 否
HY-Y1139S Pimelic acid-d4 / 否
HY-Y1217S 1-Cyclohexanol-d12 / 否
HY-Y1217S1 1-Cyclohexanol-d11 / 否
HY-Y1309S 1-Naphthol-d8 / 否
HY-Y1641S 1,2-Ethanedithiol-d4 / 否
HY-Y1772S 1-Iodo-4-methylbenzene-d7 / 否
HY-109037S2 Mavacamten-d1 Modulator / 否
HY-13678S1 Meropenem-d6-1 Inhibitor / 否
HY-17386S2 Rosiglitazone-d4-1 / 否
HY-19822S1 Elacestrant-d4-1 Inhibitor / 否
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HY-B0492S rel-Paroxetine-d4-1 hydrochloride / 否
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HY-N7092S23 D-Fructose-13C3-1 / 否
HY-W011885S 1-Dodecylpyrrolidin-2-one-d6 / 否
HY-W032013S2 1-Octanol-d2-1 Inhibitor / 否
HY-W032013S3 1-Octanol-d5 Inhibitor / 否
HY-W110726S 1-Octen-3-one-d5 / 否
HY-W110726S1 1-Octen-3-one-d3 / 否
HY-W192474S 1-(Furan-2-yl)ethane-1-thiol-d3 / 否
HY-W285163S 1-Cyclopropyl-6-fluoro-7-(4-formylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-d8 / 否
HY-W392083S (1,3E,5E)-Undeca-1,3,5-triene-d5 / 否
HY-W392083S1 (1,3E,5Z)-Undeca-1,3,5-triene-d5 / 否
HY-Y0045S 2-Acetylthiazole-13C2 / 否
HY-Y0743S 1-(Pyridin-2-yl)ethan-1-one-d6 / 否
HY-Y0921S3 (±)-1,2-Propanediol-13C3 / 否
HY-Y1004S6 1-Decanol-d2-2 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SUB1 MGD MGI:104811
Rattus norvegicus SUB1 RGD RGD:621582
Bos taurus SUB1 VGNC VGNC:35454
Macaca mulatta SUB1 VGNC VGNC:110431
Others SUB1 NCBI
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