Cx3cr1 - chemokine (C-X3-C motif) receptor 1 Gene

中文名称：趋化因子 (C-X3-C 基序) 受体 1

种属: Mus musculus

同用名: mCX3CR1

关于 Cx3cr1

功能概要

该基因编码的蛋白可启动 C-X3-C 趋化因子结合活性和 C-X3-C 趋化因子受体活性。参与多个过程，包括白细胞迁移；神经系统发育；和突触组织。作用于多个过程的上游或内部，包括巨噬细胞趋化性；参与免疫反应的小胶质细胞激活；在配体不存在的情况下外在凋亡信号通路的负调节。位于细胞表面。以多种结构表达，包括冒号；泌尿生殖系统；和肝脏。用于研究年龄相关性黄斑变性 12。该基因的人类直系同源物涉及多种疾病，包括人类免疫缺陷病毒传染病；肥胖;肺动脉高压;视网膜疾病（多发）；和系统性硬皮病。与人 CX3CR1（C-X3-C 基序趋化因子受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-X3-C chemokine binding activity and C-X3-C Chemokine Receptor activity. Involved in several processes, including leukocyte migration; nervous system development; and synapse organization. Acts upstream of or within several processes, including macrophage chemotaxis; microglial cell activation involved in immune response; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cell surface. Is expressed in several structures, including colon; genitourinary system; and liver. Used to study age related macular degeneration 12. Human ortholog(s) of this gene implicated in several diseases, including human immunodeficiency virus infectious disease; obesity; pulmonary hypertension; retinal disease (multiple); and systemic scleroderma. Orthologous to human CX3CR1 (C-X3-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]