2. Gene
  3. H2ax - H2A.X variant histone Gene

H2ax - H2A.X variant histone Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: H2A.X; H2afx; Hist5-2ax; gammaH2ax

基因 ID: 15270 | 基因类型: protein coding

关于 H2ax

功能概要

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]

H2ax 基因产物(1)

mRNA Protein Name
NM_010436.2 NP_034566.1 histone H2AX
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables damaged DNA binding IDA
IDA: 通过直接分析推断
11934988 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17304220 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT acts upstream of or within DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
11934988 MGI
acts upstream of or within DNA repair IDA
IDA: 通过直接分析推断
15364958 MGI
acts upstream of or within DNA repair IMP
IMP: 通过突变表型推断
11934988 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
11934988 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
11934988 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in XY body IDA
IDA: 通过直接分析推断
18070917 MGI
located in chromatin IDA
IDA: 通过直接分析推断
11934988 MGI
located in chromosome IDA
IDA: 通过直接分析推断
23039116 MGI
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
20551173 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
14611631 MGI
located in nucleus IDA
IDA: 通过直接分析推断
20360685 MGI
located in replication fork IDA
IDA: 通过直接分析推断
15364958 MGI
located in site of double-strand break IDA
IDA: 通过直接分析推断
22699483 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone H2AX

H2A histone family, member X

H2a/x

histone 5 protein 2ax

histone H2A.x

H2ax 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
H2ax P27661 Fancd2 Mus musculus Q80V62
Anti Bait CoIP
17304220
种属内
H2ax P27661 Aifm1 Mus musculus Q9Z0X1
Anti Tag CoIP
20360685
种属内
H2ax P27661 Aifm1 Mus musculus Q9Z0X1
Confocal
20360685
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-12037A Rigosertib 99.01% Phase 3
HY-12037 Rigosertib sodium 99.57% Phase 3
HY-18174 Prexasertib 98.74% Phase 2
HY-18174A Prexasertib dihydrochloride 99.73% Phase 2
HY-18174E Prexasertib dimesylate 98.90% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-117693 (E/Z)-Mirin Inhibitor 99.22% 否
HY-123834 FEN1-IN-1 99.85% 否
HY-101089 RHPS4 99.88% 否
HY-122181B OTS186935 hydrochloride Inhibitor 99.58% 否
HY-N0316 Mollugin 99.48% 否
HY-122181 OTS186935 Inhibitor 98.55% 否
HY-103241 Ro 90-7501 99.10% 否
HY-122182 OTS193320 98.64% 否
HY-RS05957 H2AX Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-18174C Prexasertib mesylate / 否
HY-122181A OTS186935 trihydrochloride Inhibitor / 否
HY-117688 WJ35435 / 否
HY-121777 SFOM-0046 Inhibitor / 否
HY-145288 Antitumor agent-36 / 否
HY-145289 Antitumor agent-37 / 否
HY-162985 JHD205 Inhibitor / 否
HY-168877 FMP Activator / 否
HY-174989 ATM-IN-2 / 否
HY-18174H Prexasertib lactate / 否
HY-RS16644 H2ax Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23078 H2ax Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens H2ax NCBI NCBI:3014
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