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  2. EPHA3 - EPH receptor A3 Gene

EPHA3 - EPH receptor A3 Gene

中文名称:EPH 受体 A3

种属: Homo sapiens

同用名: EK4; ETK; HEK; ETK1; HEK4; TYRO4

基因 ID: 2042 | 基因类型: protein coding

关于 EPHA3

Cytogenetic location: 3p11.1 Genomic coordinates (GRCh38): 3:89,107,621-89,482,134 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues, 53 paralogues and is associated with 118 phenotypes. Broad expression in prostate (RPKM 12.7), gall bladder (RPKM 11.9) and 18 other tissues.

功能概要

该基因属于蛋白酪氨酸激酶家族的肝配蛋白受体亚家族。 EPH 和 EPH 相关受体与介导发育事件有关,特别是在神经系统中。 EPH 亚家族中的受体通常具有单个激酶结构域和一个含有富含半胱氨酸结构域和 2 个纤连蛋白 III 型重复序列的胞外区域。基于肝配蛋白受体胞外结构域序列的相似性及其结合肝配蛋白-A 和肝配蛋白-B 配体的亲和力,肝配蛋白受体分为 2 组。该基因编码一种结合 ephrin-A 配体的蛋白质。已经描述了该基因的两个选择性剪接的转录物变体。[RefSeq 提供,2008 年 7 月]

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

EPHA3 基因产物(3)

mRNA Protein Name
NM_001410778.1 NP_001397707.1 ephrin type-A receptor 3 isoform c precursor
NM_005233.6 NP_005224.2 ephrin type-A receptor 3 isoform a precursor
NM_182644.3 NP_872585.1 ephrin type-A receptor 3 isoform b precursor

EPHA3 蛋白结构

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (29 - 202)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (268 - 303)

fn3

fn3: Fibronectin type III domain (327 - 416)

fn3

fn3: Fibronectin type III domain (444 - 521)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (544 - 618)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (622 - 878)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (908 - 973)

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  • 983 a.a.
蛋白主名 其他名称

ephrin type-A receptor 3

EPH-like kinase 4

重组 EPHA3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71663 EphA3 Protein, Human (HEK293, His) P29320 (E21-Q541) ≥95%
HY-P72017 EphA3 Protein, Human (HEK 293, His) P29320 (S21-Q541) ≥95%

关联疾病

疾病名称 别名
Wet Beriberi
Thiamine Deficiency Disease
Beriberi

Thiamine Deficiency

Vitamin B1 Deficiency

Aneurin Deficiency

Thiamine Vitamin Deficiency

Beriberi Nos

Beriberi Due To Vitamin B1 Deficiency

Beriberi Due To Thiamine Vitamin Deficiency

Kakkè

Ciliary Dyskinesia, Primary, 20

Primary Ciliary Dyskinesia 20

CILD20

Primary Ciliary Dyskinesia 20 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 20, With Or Without Situs Inversus

Ics20

Immotile Cilia Syndrome 20

Dyskinesia, Ciliary, Primary, 20

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Pseudohypoaldosteronism
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus EPHA3 MGD MGI:99612
Rattus norvegicus EPHA3 RGD RGD:68389
Bos taurus EPHA3 VGNC VGNC:54423
Macaca mulatta EPHA3 VGNC VGNC:72236
Felis catus EPHA3 VGNC VGNC:61903
Canis familiaris EPHA3 VGNC VGNC:40406
Others EPHA3 NCBI