2. Gene
  3. FCGRT - Fc gamma receptor and transporter Gene

FCGRT - Fc gamma receptor and transporter Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Fc γ 受体和转运体

种属: Homo sapiens

同用名: FCRN; FcgammaRn; alpha-chain

基因 ID: 2217 | 基因类型: protein coding

关于 FCGRT

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,512,661-49,526,428 (from NCBI)

This gene has 18 transcripts (splice variants), 352 orthologues and 22 paralogues. Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues.

功能概要

该基因编码一个受体，该受体结合单体免疫球蛋白 G 的 Fc 区。编码的蛋白质将免疫球蛋白 G 抗体从母亲转移到胎盘中的胎儿。该蛋白质还结合免疫球蛋白 G 以保护抗体免于降解。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 4 月]

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G Antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

FCGRT 基因产物(3)

mRNA Protein Name
NM_001136019.3 NP_001129491.1 IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001411064.1 NP_001397993.1 IgG receptor FcRn large subunit p51 isoform 2 precursor
NM_004107.5 NP_004098.1 IgG receptor FcRn large subunit p51 isoform 1 precursor

FCGRT 蛋白结构

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (28 - 197)

C1-set

C1-set: Immunoglobulin C1-set domain (217 - 286)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
蛋白主名 其他名称

IgG receptor FcRn large subunit p51

Fc fragment of IgG receptor and transporter

重组 FCGRT 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70601 FCRN-B2M Protein, Human (HEK293, His) AAF72596 (A24-S297)&P61769 (I21-M119) ≥95%
HY-P71664 FCGRT Protein, Human (HEK293, His) P55899 (A24-S297) ≥95%
HY-P72192 FCGRT Protein, Human (GST) P55899 (A24-S297) ≥95%
HY-P72368 FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi) AAF72596 (A24-S297)&P61769 (I21-M119) ≥95%
HY-P73522 FCGRT-B2M Heterodimer Protein, Human (HEK293, His) P55899 (A24-S297)&P61769 (I21-M119) ≥95%
HY-P77666 FCGRT-B2M Heterodimer Protein, Human (373a.a, HEK293, His) P55899 (A24-S297)&P61769 (I21-M119) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 43

Hypoproteinemia, Hypercatabolic

IMD43

Beta-2-Microglobulin Deficiency

B2m Deficiency

Hypercatabolic Hypoproteinemia
Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation

Fetal Circulation

Persistent Pulmonary Hypertension Of The Newborn

Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Persistent Foetal Circulation

Persistent Foetal Circulation Syndrome

Pfc - [Persistent Fetal Circulation] Syndrome

Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

Newborn Pulmonary Hypertension

Primary Pulmonary Hypertension Of Newborn
Immunoglobulin G Deficiency

Igg Deficiency

Igg Subclass Deficiency
Tetanus Neonatorum

Neonatal Tetanus

NNT

Trismus Neonatorum

Newborn Trismus
Epidermolysis Bullosa Acquisita

Acquired Epidermolysis Bullosa

Eb Acquisita

Eba

Eba - [Epidermolysis Bullosa Acquisita]
Neonatal Myasthenia Gravis

Myasthenia Gravis, Neonatal
Pemphigus
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Ankylosing Spondylitis 3
Transient Hypogammaglobulinemia
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Heart Block, Congenital

Congenital Heart Block

Heart Block Congenital

Congenital Atrioventricular Block
Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia

Autoimmune Thrombocytopenia

Immune Thrombocytopenic Purpura

Itp

Auto-Immune Thrombocytopenia

Thrombocytopenia Due To Immune Destruction

Autoimmune Thrombocytopenic Purpura

Idiopathic Thrombocytopenic Purpura

Werlhof Disease
Fetal Erythroblastosis

Erythroblastosis, Fetal

Ef - Erythroblastosis Foetalis

Erythroblastosis Fetalis

Haemolytic Disease Due To Rhesus Isoimmunisation

Rhesus Isoimmunisation Of The Newborn
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Brachydactyly, Type D

Brachydactyly Type D

BDD

Stub Thumb

Brachydactyly D
Factor Viii Deficiency

Autosomal Hemophilia A

Hemophilia A

Autosomal Factor Viii Deficiency

Classic Hemophilia A

Congenital Factor Viii Disorder

Subhemophilia

Factor 8 Deficiency, Congenital

Factor Viii
Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy
Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

Atypical Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To

Ahus

AHUS1

Hemolytic-Uremic Syndrome

Ahus 1

Ahus, Susceptibility To, 1

Hemolytic Uremic Syndrome, Atypical

Non-Shiga-Like Toxin-Associated Hus

Non-Stx-Hus

Nonenteropathic Hus

Atypical Hus

Shiga Toxin-Associated Hemolytic Uremic Syndrome

D+ Hus

Ehec-Hus

Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

Hemolytic Uremic Syndrome With Diarrhea

Stec-Hus

Shiga-Like Toxin-Associated Hus

Stx-Hus

Typical Hus

Typical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

Atypical Hus With Anti-Factor H Antibodies

Ahus With Anti-Factor H Antibodies

Ahus With Neutralizing Autoantibodies Against Factor H

Hemolytic Uremic Syndrome Atypical 1

Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

D Hus

Hemolytic-Uremic Syndrome Without Diarrhea

Hemolytic-Uremic Syndrome, Atypical, Type 1

Hemolytic Uremic Syndrome, Typical
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04833 FCGRT Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FCGRT VGNC VGNC:62209
Rattus norvegicus FCGRT RGD RGD:61811
Canis familiaris FCGRT VGNC VGNC:40803
Mus musculus FCGRT MGD MGI:103017
Bos taurus FCGRT VGNC VGNC:28934
Macaca fascicularis FCGRT NCBI
Macaca mulatta FCGRT NCBI
Others FCGRT NCBI
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