1. Gene
  2. SGK3 - serum/glucocorticoid regulated kinase family member 3 Gene

SGK3 - serum/glucocorticoid regulated kinase family member 3 Gene

中文名称:血清/糖皮质激素调节激酶家族成员 3

种属: Homo sapiens

同用名: CISK; SGK2; SGKL

基因 ID: 23678 | 基因类型: protein coding

关于 SGK3

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,712,781-66,862,022 (from NCBI)

This gene has 14 transcripts (splice variants), 212 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), kidney (RPKM 5.7) and 25 other tissues.

功能概要

该基因是 Ser/Thr 蛋白激酶家族的成员,编码具有 PX (phox 同源) 结构域的磷蛋白。该蛋白磷酸化几种靶蛋白,并在中性氨基酸转运和钾通道和氯通道激活中发挥作用。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供,2008 年 7 月]

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SGK3 基因产物(3)

mRNA Protein Name
NM_013257.5 NP_037389.4 serine/threonine-protein kinase Sgk3 isoform 1
NM_001033578.3 NP_001028750.1 serine/threonine-protein kinase Sgk3 isoform 1
NM_170709.3 NP_733827.2 serine/threonine-protein kinase Sgk3 isoform 2

SGK3 蛋白结构

PX

PX: PX domain (16 - 119)

Pkinase

Pkinase: Protein kinase domain (163 - 419)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (440 - 491)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Sgk3

cytokine-independent survival kinase

重组 SGK3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76063 SGK3 Protein, Human (sf9, GST) Q96BR1-1 (M1-L496) ≥95%

关联疾病

疾病名称 别名
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SGK3 VGNC VGNC:81696
Mus musculus SGK3 MGD MGI:2182368
Rattus norvegicus SGK3 RGD RGD:620242