1. Gene
  2. GCA - grancalcin Gene

GCA - grancalcin Gene

中文名称:颗粒钙素

种属: Homo sapiens

同用名: GCL

基因 ID: 25801 | 基因类型: protein coding

关于 GCA

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,318,763-162,375,396 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 47.3), appendix (RPKM 18.4) and 18 other tissues.

功能概要

该基因编码的钙结合蛋白在中性粒细胞和巨噬细胞中含量丰富。在没有二价阳离子的情况下,该蛋白质定位于胞质部分;单独使用镁时,它与颗粒部分分离;在镁和钙存在的情况下,它与颗粒和膜部分结合。替代剪接和替代启动子的使用导致多个转录变体。[RefSeq 提供,2016 年 8 月]

This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GCA 基因产物(7)

mRNA Protein Name
NM_001330265.1 NP_001317194.1 grancalcin isoform a
NM_001330266.1 NP_001317195.1 grancalcin isoform a
NM_001330267.1 NP_001317196.1 grancalcin isoform a
NM_001330268.1 NP_001317197.1 grancalcin isoform c
NM_001330270.2 NP_001317199.1 grancalcin isoform d
NM_001330271.2 NP_001317200.1 grancalcin isoform d
NM_012198.5 NP_036330.1 grancalcin isoform b

GCA 蛋白结构

EF-hand_8

EF-hand_8: EF-hand domain pair (64 - 119)

EF-hand_6

EF-hand_6: EF-hand domain (125 - 150)

  • 0
  • 100
  • 200
  • 217 a.a.
蛋白主名 其他名称

grancalcin

grancalcin, EF-hand calcium-binding protein

重组 GCA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70334 Grancalcin/GCA Protein, Human (His) P28676 (M1-I217) ≥95%
HY-P72635 Grancalcin/GCA Protein, Human (GST) P28676 (M1-I217) ≥95%

直系同源

种属 基因名 来源 基因 ID
Mus musculus GCA MGD MGI:1918521
Macaca mulatta GCA VGNC VGNC:72726
Canis familiaris GCA VGNC VGNC:41137
Rattus norvegicus GCA RGD RGD:1306589
Felis catus GCA VGNC VGNC:80217
Bos taurus GCA VGNC VGNC:29278
Others GCA NCBI