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  2. HSP90AB1 - heat shock protein 90 alpha family class B member 1 Gene

HSP90AB1 - heat shock protein 90 alpha family class B member 1 Gene

中文名称:热休克蛋白 90 α 家族 B 类成员 1

种属: Homo sapiens

同用名: HSP84; HSPC2; HSPCB; D6S182; HSP90B

基因 ID: 3326 | 基因类型: protein coding

关于 HSP90AB1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,246,194-44,253,883 (from NCBI)

This gene has 4 transcripts (splice variants), 229 orthologues, 3 paralogues and is associated with 64 phenotypes. Ubiquitous expression in ovary (RPKM 514.6), brain (RPKM 324.0) and 25 other tissues.

功能概要

该基因编码热休克蛋白 90 家族的一个成员;这些蛋白质参与信号转导、蛋白质折叠和降解以及形态进化。该基因编码胞质 90 kDa 热休克蛋白的组成型,被认为在胃细胞凋亡和炎症中发挥作用。可变剪接导致多个转录本变体。已在多条染色体上鉴定出假基因。[RefSeq 提供,2012 年 12 月]

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric Apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

HSP90AB1 基因产物(6)

mRNA Protein Name
NM_001271969.2 NP_001258898.1 heat shock protein HSP 90-beta isoform a
NM_001271970.2 NP_001258899.1 heat shock protein HSP 90-beta isoform a
NM_001271971.2 NP_001258900.1 heat shock protein HSP 90-beta isoform b
NM_001271972.2 NP_001258901.1 heat shock protein HSP 90-beta isoform c
NM_001371238.1 NP_001358167.1 heat shock protein HSP 90-beta isoform a
NM_007355.4 NP_031381.2 heat shock protein HSP 90-beta isoform a

HSP90AB1 蛋白结构

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (36 - 187)

HSP90

HSP90: Hsp90 protein (191 - 724)

  • 0
  • 200
  • 400
  • 600
  • 724 a.a.
蛋白主名 其他名称

heat shock protein HSP 90-beta

HSP90-beta

关联疾病

疾病名称 别名
Powassan Encephalitis

Powassan Encephalitis Virus Infection

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus HSP90AB1 VGNC VGNC:55918
Macaca mulatta HSP90AB1 VGNC VGNC:81078
Mus musculus HSP90AB1 MGD MGI:96247
Rattus norvegicus HSP90AB1 RGD RGD:1303075
Others HSP90AB1 NCBI