MDK - midkine Gene

中文名称：中期因子

种属: Homo sapiens

同用名: MK; ARAP; NEGF2

基因 ID: 4192 | 基因类型: protein coding

关于 MDK

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,380,784-46,383,837 (from NCBI)

This gene has 12 transcripts (splice variants), 247 orthologues and 1 paralogue. Broad expression in ovary (RPKM 88.5), endometrium (RPKM 55.5) and 14 other tissues.

功能概要

该基因编码一个分泌性生长因子家族的成员，该家族可结合肝素并对视黄酸产生反应。编码的蛋白质促进细胞生长、迁移和血管生成，特别是在肿瘤发生过程中。该基因已被靶向作为多种不同疾病的治疗剂。已经观察到编码多种同种型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

MDK 基因产物(6)

mRNA	Protein	Name
NM_001012333.3	NP_001012333.1	midkine isoform a precursor
NM_001012334.2	NP_001012334.1	midkine isoform a precursor
NM_001270550.1	NP_001257479.1	midkine isoform a precursor
NM_001270551.3	NP_001257480.1	midkine isoform a precursor
NM_001270552.3	NP_001257481.1	midkine isoform b precursor
NM_002391.6	NP_002382.1	midkine isoform a precursor

MDK 蛋白结构

PTN_MK_N

PTN_MK_C

0
100
143 a.a.

蛋白主名

其他名称

midkine

amphiregulin-associated protein

重组 MDK 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71941	MDK Protein, Human	P21741 (V21-D143)	≥95%
HY-P73295	MDK Protein, Human (sf9)	P21741-1 (V21-D143)	≥95%
HY-P700138AF	Animal-Free MDK Protein, Human (His)	P21741-1 (V21-D143)	≥95%
HY-P700791	MDK/Midkine Protein, Human (His-Avi)	P21741-1 (V21-D143)	≥95%
HY-P701024	MDK/Midkine Protein, Human (Biotinylated, His-Avi)	P21741-1 (V21-D143)	≥95%

关联疾病

疾病名称

别名

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-110171	iMDK	Inhibitor	99.34%	否
HY-110171A	iMDK quarterhydrate	Inhibitor	99.34%	否
HY-18633	MDK83190	Activator	98.40%	否
HY-RS08262	MDK Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MDK	RGD	RGD:69073
Mus musculus	MDK	MGD	MGI:96949
Felis catus	MDK	VGNC	VGNC:68222
Bos taurus	MDK	VGNC	VGNC:49556
Others	MDK	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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MDK - midkine Gene

关于 MDK

功能概要

MDK 基因产物(6)

MDK 蛋白结构

重组 MDK 蛋白

关联疾病

直系同源

热门区域

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MDK - midkine Gene

关于 MDK

功能概要

MDK 基因产物(6)

MDK 蛋白结构

重组 MDK 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z