ATF1 - activating transcription factor 1 Gene

中文名称：激活转录因子 1

种属: Homo sapiens

同用名: TREB36; EWS-ATF1; FUS/ATF-1

基因 ID: 466 | 基因类型: protein coding

关于 ATF1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,763,459-50,821,162 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues, 9 paralogues and is associated with 66 phenotypes. Ubiquitous expression in thyroid (RPKM 6.8), adrenal (RPKM 5.9) and 25 other tissues.

功能概要

该基因编码一个激活转录因子，属于 ATF 亚家族和 bZIP (碱性区亮氨酸拉链) 家族。它通过调节与生长、存活和其他细胞活动相关的下游靶基因的表达来影响细胞生理过程。该蛋白在其激酶诱导结构域的第 63 位丝氨酸被丝氨酸/苏氨酸激酶、cAMP 依赖性蛋白激酶 A、钙调蛋白依赖性蛋白激酶 I/II、有丝分裂原和应激激活蛋白激酶以及细胞周期蛋白依赖性激酶 3 磷酸化 ( cdk-3) .其磷酸化增强其反式激活和转录活性，并增强细胞转化。该基因与 16 号染色体上的 FUS 或 22 号染色体上易位诱导的 EWSR1 融合，在血管瘤样纤维组织细胞瘤和透明细胞肉瘤中产生嵌合蛋白。该基因在 6 号染色体上有一个假基因。[RefSeq 提供，2010 年 8 月]

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

ATF1 基因产物(25)

mRNA	Protein	Name
NM_001412960.1	NP_001399889.1	cyclic AMP-dependent transcription factor ATF-1 isoform a
NM_001412961.1	NP_001399890.1	cyclic AMP-dependent transcription factor ATF-1 isoform b
NM_001412962.1	NP_001399891.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412963.1	NP_001399892.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412964.1	NP_001399893.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412965.1	NP_001399894.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412966.1	NP_001399895.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412967.1	NP_001399896.1	cyclic AMP-dependent transcription factor ATF-1 isoform c
NM_001412968.1	NP_001399897.1	cyclic AMP-dependent transcription factor ATF-1 isoform d
NM_001412969.1	NP_001399898.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412970.1	NP_001399899.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412971.1	NP_001399900.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412972.1	NP_001399901.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412973.1	NP_001399902.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412974.1	NP_001399903.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412975.1	NP_001399904.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412976.1	NP_001399905.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412977.1	NP_001399906.1	cyclic AMP-dependent transcription factor ATF-1 isoform e
NM_001412978.1	NP_001399907.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412979.1	NP_001399908.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412980.1	NP_001399909.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412981.1	NP_001399910.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412982.1	NP_001399911.1	cyclic AMP-dependent transcription factor ATF-1 isoform f
NM_001412983.1	NP_001399912.1	cyclic AMP-dependent transcription factor ATF-1 isoform g
NM_005171.5	NP_005162.1	cyclic AMP-dependent transcription factor ATF-1 isoform c

ATF1 蛋白结构

pKID

bZIP_1

0
100
200
271 a.a.

蛋白主名

其他名称

cyclic AMP-dependent transcription factor ATF-1

cAMP-dependent transcription factor ATF-1

重组 ATF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7615	ATF1 Protein, Human (His)	P18846 (M1-V271)	≥95%

关联疾病

疾病名称

别名

Melanoma Of Soft Tissue

Clear Cell Sarcoma Of The Tendons And Aponeuroses

Fibrous Histiocytoma

Benign Fibrous Histiocytoma	Histiocytoma, Benign Fibrous
Fibroxanthoma	Histiocytoma Fibrous

Clear Cell Sarcoma

Sarcoma, Clear Cell	Adult Soft Part Clear Cell Sarcoma
Clear Cell Sarcoma Of Soft Parts	Malignant Melanoma Of Soft Parts
Malignant Melanoma Of Soft Tissues	Melanoma, Malignant, Of Soft Parts
Sarcoma Clear Cell

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Myxoid Chondrosarcoma

Sarcomatosis

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108618	BC11-38	Inhibitor	99.42%	否
HY-N12887	Mycothiazole	Inhibitor	/	否
HY-RS01127	ATF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ATF1	VGNC	VGNC:38207
Rattus norvegicus	ATF1	RGD	RGD:1307360
Felis catus	ATF1	VGNC	VGNC:83504
Macaca mulatta	ATF1	VGNC	VGNC:108325
Mus musculus	ATF1	MGD	MGI:1298366
Bos taurus	ATF1	VGNC	VGNC:26239
Others	ATF1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

ATF1 - activating transcription factor 1 Gene

关于 ATF1

功能概要

ATF1 基因产物(25)

ATF1 蛋白结构

重组 ATF1 蛋白

关联疾病

直系同源

热门区域

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ATF1 - activating transcription factor 1 Gene

关于 ATF1

功能概要

ATF1 基因产物(25)

ATF1 蛋白结构

重组 ATF1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z