2. Gene
  3. CLEC1B - C-type lectin domain family 1 member B Gene

CLEC1B - C-type lectin domain family 1 member B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：C 型凝集素结构域家族 1 成员 B

种属: Homo sapiens

同用名: CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik

基因 ID: 51266 | 基因类型: protein coding

关于 CLEC1B

Cytogenetic location: 12p13.31-p13.2 Genomic coordinates (GRCh38): 12:9,993,075-10,001,899 (from NCBI)

This gene has 4 transcripts (splice variants), 365 orthologues and 23 paralogues. Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue.

功能概要

自然杀伤 (NK) 细胞表达多种钙依赖性 (C 型) 凝集素样受体，例如 CD94 (KLRD1；MIM 602894) 和 NKG2D (KLRC4；MIM 602893) ，它们与主要组织相容性复合物 I 类分子相互作用，并且抑制或激活细胞毒性和细胞因子分泌。 CLEC2 是一种在骨髓细胞和 NK 细胞中表达的 C 型凝集素样受体 (Colonna 等人，2000 [PubMed 10671229]) 。[OMIM 提供，2011 年 1 月]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

CLEC1B 基因产物(3)

mRNA Protein Name
NM_001099431.2 NP_001092901.1 C-type lectin domain family 1 member B isoform b
NM_001393342.1 NP_001380271.1 C-type lectin domain family 1 member B isoform a
NM_016509.4 NP_057593.3 C-type lectin domain family 1 member B isoform a

CLEC1B 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (120 - 218)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

C-type lectin domain family 1 member B

C-type lectin-like receptor 2

重组 CLEC1B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75336 CLEC1B/CLEC-2 Protein, Human (HEK293, His) Q9P126 (Q58-P229) ≥95%

关联疾病

疾病名称 别名
Bleeding Disorder, Platelet-Type, 11

BDPLT11

Glycoprotein Vi Deficiency

Gp Vi Deficiency

Platelet-Type Bleeding Disorder 11

Bleeding Diathesis Due To A Collagen Receptor Defect

Bleeding Diathesis Due To Glycoprotein Vi Deficiency

Platelet-Type Bleeding Disorder-11

Bleeding Disorder, Platelet Type 11

Hemorrhage
Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids
Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder

Epidermoid Carcinoma Of The Urinary Bladder

Carcinoma Squamous Cell Bladder
Blood Platelet Disease

Platelet Disorder

Blood Platelet Disorders

Thrombocytopathy

Platelet Dysfunction

Platelet Disorders

Qualitative Platelet Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02786 CLEC1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CLEC1B RGD RGD:1563517
Felis catus CLEC1B VGNC VGNC:60946
Bos taurus CLEC1B VGNC VGNC:58366
Canis familiaris CLEC1B VGNC VGNC:49802
Macaca mulatta CLEC1B VGNC VGNC:71336
Mus musculus CLEC1B MGD MGI:1913287
Others CLEC1B NCBI
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