DPP10 - dipeptidyl peptidase like 10 Gene

中文名称：二肽基肽酶样 10

种属: Homo sapiens

同用名: DPL2; DPPY; DPRP3; DPRP-3

基因 ID: 57628 | 基因类型: protein coding

关于 DPP10

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:114,442,641-115,845,780 (from NCBI)

This gene has 13 transcripts (splice variants), 272 orthologues and 6 paralogues. Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues.

功能概要

该基因编码一种单程 II 型膜蛋白，它是丝氨酸蛋白酶家族 SC 中 S9B 家族的成员。这种蛋白质没有可检测的蛋白酶活性，很可能是由于不存在通常存在于丝氨酸蛋白酶催化结构域中的保守丝氨酸残基。然而，它确实结合了特定的电压门控钾通道并改变了它们的表达和生物物理特性。该基因的突变与哮喘有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DPP10 基因产物(18)

mRNA	Protein	Name
NM_001004360.5	NP_001004360.3	inactive dipeptidyl peptidase 10 isoform short
NM_001178034.1	NP_001171505.1	inactive dipeptidyl peptidase 10 isoform c
NM_001178036.3	NP_001171507.2	inactive dipeptidyl peptidase 10 isoform a
NM_001178037.3	NP_001171508.2	inactive dipeptidyl peptidase 10 isoform b
NM_001321905.3	NP_001308834.2	inactive dipeptidyl peptidase 10 isoform d
NM_001321906.2	NP_001308835.2	inactive dipeptidyl peptidase 10 isoform short
NM_001321907.3	NP_001308836.2	inactive dipeptidyl peptidase 10 isoform e
NM_001321908.3	NP_001308837.2	inactive dipeptidyl peptidase 10 isoform f
NM_001321909.3	NP_001308838.2	inactive dipeptidyl peptidase 10 isoform g
NM_001321910.3	NP_001308839.2	inactive dipeptidyl peptidase 10 isoform a
NM_001321911.3	NP_001308840.2	inactive dipeptidyl peptidase 10 isoform a
NM_001321912.3	NP_001308841.2	inactive dipeptidyl peptidase 10 isoform h
NM_001321913.3	NP_001308842.2	inactive dipeptidyl peptidase 10 isoform i
NM_001321914.2	NP_001308843.2	inactive dipeptidyl peptidase 10 isoform i
NM_001399849.1	NP_001386778.1	inactive dipeptidyl peptidase 10 isoform a
NM_001399850.1	NP_001386779.1	inactive dipeptidyl peptidase 10 isoform i
NM_001399851.1	NP_001386780.1	inactive dipeptidyl peptidase 10 isoform j
NM_020868.6	NP_065919.3	inactive dipeptidyl peptidase 10 isoform long

DPP10 蛋白结构

DPPIV_N

Peptidase_S9

0
200
400
600
796 a.a.

蛋白主名

其他名称

inactive dipeptidyl peptidase 10

DPP X

重组 DPP10 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75281	DPP10 Protein, Human (HEK293, His)	Q8N608-1 (L56-E796)	≥95%

关联疾病

疾病名称

别名

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Near-Fatal Asthma

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03961	DPP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DPP10	VGNC	VGNC:61602
Bos taurus	DPP10	VGNC	VGNC:28186
Mus musculus	DPP10	MGD	MGI:2442409
Canis familiaris	DPP10	VGNC	VGNC:40072
Rattus norvegicus	DPP10	RGD	RGD:1306427
Macaca mulatta	DPP10	VGNC	VGNC:71873
Others	DPP10	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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