CCL23 - C-C motif chemokine ligand 23 Gene

中文名称：CC 基序趋化因子配体 23

种属: Homo sapiens

同用名: CKb8; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; hmrp-2a; CK-BETA-8

关于 CCL23

功能概要

该基因是聚集在 17 号染色体 q 臂上的几个趋化因子基因之一。趋化因子形成参与免疫调节和炎症过程的分泌蛋白超家族。基于成熟肽的 N 末端半胱氨酸残基的排列，该超家族分为四个亚家族。这种趋化因子是 CC 亚家族的成员，对静息 T 淋巴细胞和单核细胞显示趋化活性，对中性粒细胞活性较低，对活化 T 淋巴细胞无活性。该蛋白质也是多能造血祖细胞系集落形成的强抑制剂。此外，该基因的产物是趋化因子 (CC 基序) 受体 1 的有效激动剂。可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2013 年 7 月]

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]