SSTR1 - somatostatin receptor 1 Gene

中文名称：生长抑素受体 1

种属: Homo sapiens

同用名: SS1R; SST1; SS1-R; SRIF-2; SS-1-R

基因 ID: 6751 | 基因类型: protein coding

关于 SSTR1

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:38,207,904-38,213,067 (from NCBI)

This gene has 1 transcript (splice variant), 160 orthologues and 17 paralogues. Biased expression in stomach (RPKM 11.3), duodenum (RPKM 7.3) and 9 other tissues.

功能概要

生长抑素是调节多种细胞功能 (例如神经传递、细胞增殖和内分泌信号传导) 以及抑制许多激素和其他分泌蛋白的释放的肽类激素。生长抑素有 14 和 28 个氨基酸的两种活性形式。生长抑素的生物学效应由以组织特异性方式表达的 G 蛋白偶联生长抑素受体家族介导。由该基因编码的蛋白质是具有七个跨膜片段的生长抑素受体超家族的成员。生长抑素受体与超家族的其他成员以及其他 G 蛋白偶联受体和受体酪氨酸激酶形成同二聚体和异二聚体。这种生长抑素受体对生长抑素 14 的亲和力大于对 -28 的亲和力。[RefSeq 提供，2012 年 7 月]

Somatostatins are peptide Hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many Hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 Amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and Receptor Tyrosine Kinases. This Somatostatin Receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

SSTR1 基因产物(2)

mRNA	Protein	Name
XM_047431728.1	XP_047287684.1	somatostatin receptor type 1 isoform X1
NM_001049.3	NP_001040.1	somatostatin receptor type 1

SSTR1 蛋白结构

7tm_1

0
100
200
300
391 a.a.

蛋白主名

其他名称

somatostatin receptor type 1

关联疾病

疾病名称

别名

Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri	Benign Intracranial Hypertension
Idiopathic Intracranial Hypertension	Iih
Benign Intracran. Hypt.

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Fmtc
Mtc1	Thyroid Cancer, Medullary
Medullary Thyroid Cancer	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Pituitary Adenoma

Pituitary Neoplasms	Adenoma Of The Pituitary Gland
Pituitary Adenomas	Adenoma, Pituitary
Pituitary Gland Adenoma

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma	Corticotroph Adenoma
Corticotropinoma	Pituitary-Dependent Cushing'S Disease
Adrenal Gland Hyperfunction	Cushing Syndrome

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Serotonin Syndrome

Serotonergic Syndrome	Serotonin Storm
Serotonin Toxicity	Serotonin Toxidrome
Malignant Carcinoid Syndrome

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor	Pituitary Tumors, Hormone Producing
Somatotropinoma	Growth Hormone-Producing Pituitary Gland Neoplasm

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Microcystic Meningioma

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Hyperpituitarism

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-105172	TT-232	Agonist	98.96%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1206	CH 275	Agonist	99.71%	否
HY-P4452	PRL 2915	Antagonist	99.57%	否
HY-P3618	Cortistatin 29		99.22%	否
HY-P4469	PRL 3195	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SSTR1	VGNC	VGNC:35325
Macaca mulatta	SSTR1	VGNC	VGNC:99246
Canis familiaris	SSTR1	VGNC	VGNC:46843
Mus musculus	SSTR1	MGD	MGI:98327
Felis catus	SSTR1	VGNC	VGNC:80832
Rattus norvegicus	SSTR1	RGD	RGD:3762

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

SSTR1 - somatostatin receptor 1 Gene

关于 SSTR1

功能概要

SSTR1 基因产物(2)

SSTR1 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

SSTR1 - somatostatin receptor 1 Gene

关于 SSTR1

功能概要

SSTR1 基因产物(2)

SSTR1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z