Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

中文名称：盘基蛋白结构域 受体酪氨酸激酶 2

种属: Rattus norvegicus

同用名: Tyro10

关于 Ddr2

功能概要

该基因编码的蛋白可启动胶原蛋白结合活性。参与多个过程，包括细胞死亡的负调节；细胞群增殖的正向调节；胶原生物合成过程的正向调控。位于顶端质膜。用于研究酒精性肝硬化。酒精性肝硬化的生物标志物。该基因的人类直系同源物与胃肠道系统癌症有关（多个）；骨关节炎;和脊椎骨骨骺发育不良，短肢手型。与人类 DDR2（盘状蛋白结构域受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables collagen binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of cell population proliferation; and positive regulation of collagen biosynthetic process. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]