Tnks2 - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 Gene

中文名称：tankyrase，TRF1 相互作用锚蛋白相关的 ADP 核糖聚合酶 2

种属: Mus musculus

同用名: ARTD6; Tank2; TNKS-2; 5430432P15Rik

基因 ID: 74493 | 基因类型: protein coding

关于 Tnks2

Chromosome 19: 36,811,632-36,870,877 forward strand.GRCm39:CM001012.3

This gene has 9 transcripts (splice variants), 169 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in placenta adult (RPKM 24.7), CNS E11.5 (RPKM 2.9) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动酶结合活性；戊糖基转移酶活性；和蛋白质 N 末端结合活性。在生长调节的上游或内部起作用。预计位于核包膜内；周围物质；和细胞质的核周区。预计在细胞质和细胞核中有活性。以多种结构表达，包括消化系统；脑;眼睛;泌尿生殖系统；和外皮系统。与人 TNKS2（端锚聚合酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Enzyme binding activity; pentosyltransferase activity; and protein N-terminus binding activity. Acts upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tnks2 基因产物(1)

mRNA	Protein	Name
NM_001163635.1	NP_001157107.1	poly [ADP-ribose] polymerase tankyrase-2

Tnks2 蛋白结构

PTZ00322

ANK

PHA02876

ANK

PHA03095

ANK

SAM_tankyrase1,2

tankyrase_like

0
200
400
600
800
1000
1166 a.a.

蛋白主名

其他名称

poly [ADP-ribose] polymerase tankyrase-2

ADP-ribosyltransferase diphtheria toxin-like 6	TRF1-interacting ankyrin-related ADP-ribose polymerase 2
protein poly-ADP-ribosyltransferase tankyrase-2	tankyrase II
tankyrase-2	tankyrase-like protein
tankyrase-related protein

相关产品

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

生物活性分子 (31)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15147	XAV-939	Inhibitor	99.91%	否
HY-12438	G007-LK	Inhibitor	99.42%	否
HY-13990	NVP-TNKS656		99.66%	否
HY-12975	AZ6102	Inhibitor	99.65%	否
HY-13968	JW 55	Inhibitor	98.95%	否
HY-16910	WIKI4	Inhibitor	99.93%	否
HY-19351	MN-64	Inhibitor	99.73%	否
HY-148063	DB0614		98.80%	否
HY-U00422	K-756	Inhibitor	99.76%	否
HY-145267	OM-153	Inhibitor	99.59%	否
HY-123851	MSC2504877	Inhibitor	98.50%	否
HY-101243	XMD16-5	Inhibitor	98.59%	否
HY-15811	XMD8-87	Inhibitor	98.63%	否
HY-121719	TIQ-A	Inhibitor	99.65%	否
HY-143338	ART-IN-1	Inhibitor	98.91%	否
HY-147886	PARP1-IN-11	Inhibitor	98.58%	否
HY-148061	DB1113		99.28%	否
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	否
HY-100847	AZ0108	Inhibitor	/	否
HY-145111	TNK2-IN-1	Inhibitor	/	否
HY-145266	OM-1700	Inhibitor	/	否
HY-146336	PARP1/2/TNKS1/2-IN-1		/	否
HY-148065	FMF-06-098-1		/	否
HY-153259	TNKS1/2-IN-2	Inhibitor	/	否
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	否
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	否
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-153332	Tankyrase-IN-5	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Tnks2	NCBI	NCBI:80351

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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