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  3. TET1 - tet methylcytosine dioxygenase 1 Gene

TET1 - tet methylcytosine dioxygenase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：tet 甲基胞嘧啶双加氧酶 1

种属: Homo sapiens

同用名: LCX; CXXC6; bA119F7.1

基因 ID: 80312 | 基因类型: protein coding

关于 TET1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,560,337-68,694,487 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues, 2 paralogues and is associated with 106 phenotypes. Low expression observed in reference dataset.

功能概要

DNA 甲基化是一种表观遗传机制，对控制基因表达很重要。该基因编码的蛋白质是一种属于 TET (十-十一易位) 家族的去甲基化酶。 TET 蛋白家族的成员在 DNA 甲基化过程和基因激活中发挥作用。[RefSeq 提供，2015 年 9 月]

DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET Protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]

TET1 基因产物(12)

mRNA Protein Name
NM_001406365.1 NP_001393294.1 methylcytosine dioxygenase TET1 isoform 1
NM_001406367.1 NP_001393296.1 methylcytosine dioxygenase TET1 isoform 3
NM_001406368.1 NP_001393297.1 methylcytosine dioxygenase TET1 isoform 4
NM_001406369.1 NP_001393298.1 methylcytosine dioxygenase TET1 isoform 4
NM_001406370.1 NP_001393299.1 methylcytosine dioxygenase TET1 isoform 4
NM_001406371.1 NP_001393300.1 methylcytosine dioxygenase TET1 isoform 5
NM_001406372.1 NP_001393301.1 methylcytosine dioxygenase TET1 isoform 5
NM_001406373.1 NP_001393302.1 methylcytosine dioxygenase TET1 isoform 6
NM_001406374.1 NP_001393303.1 methylcytosine dioxygenase TET1 isoform 7
NM_001406375.1 NP_001393304.1 methylcytosine dioxygenase TET1 isoform 8
NM_001406376.1 NP_001393305.1 methylcytosine dioxygenase TET1 isoform 9
NM_030625.3 NP_085128.2 methylcytosine dioxygenase TET1 isoform 2

TET1 蛋白结构

zf-CXXC

zf-CXXC: CXXC zinc finger domain (585 - 624)

Tet_JBP

Tet_JBP: Oxygenase domain of the 2OGFeDO superfamily (1580 - 2052)

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  • 2136 a.a.
蛋白主名 其他名称

methylcytosine dioxygenase TET1

CXXC finger 6

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-W396714 Succinic acid sodium Inhibitor / 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111558A Bobcat339 hydrochloride Inhibitor 99.59% 否
HY-111558 Bobcat339 Inhibitor 99.73% 否
HY-12303 OAC1 Activator 99.56% 否
HY-122258 NSC-370284 Inhibitor 96.02% 否
HY-120395 UC-514321 Inhibitor ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TET1 RGD RGD:1310993
Mus musculus TET1 MGD MGI:1098693
Canis familiaris TET1 VGNC VGNC:47260
Macaca mulatta TET1 VGNC VGNC:79811
Felis catus TET1 VGNC VGNC:66092
Bos taurus TET1 VGNC VGNC:55994
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